Immunohistochemistry (IHC)
((4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.)
Goat APXL Polyclonal Antibody | anti-SHROOM2 antibody
Goat anti-APXL Antibody
Immunohistochemistry: In paraffin embedded Human Kidney shows cytoplasm staining in PCT exclusively. Recommended concentration, 4-6ug/ml.
Immunohistochemistry (IHC)
((4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.)
Immunohistochemistry (IHC)
((4ug/ml) staining of paraffin embedded Human Kidney. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining.)
NCBI and Uniprot Product Information
NCBI Description
This gene represents the human homolog of Xenopus laevis apical protein (APX) gene, which is implicated in amiloride-sensitive sodium channel activity. It is expressed in endothelial cells and facilitates the formation of a contractile network within endothelial cells. Depletion of this gene results in an increase in endothelial sprouting, migration, and angiogenesis. This gene is highly expressed in the retina, and is a strong candidate for ocular albinism type 1 syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Uniprot Description
APXL: May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Belongs to the shroom family.
Protein type: Channel, sodium
Chromosomal Location of Human Ortholog: Xp22.3
Cellular Component: apical plasma membrane; cell-cell adherens junction; cortical actin cytoskeleton; cytoskeleton; microtubule; plasma membrane; tight junction
Molecular Function: actin binding; actin filament binding; amiloride-sensitive sodium channel activity; beta-catenin binding; protein binding
Biological Process: actin filament bundle formation; apical protein localization; brain development; camera-type eye development; camera-type eye morphogenesis; cell migration; cell morphogenesis; cellular pigment accumulation; ear development; establishment of melanosome localization; eye pigment granule organization and biogenesis; lens morphogenesis in camera-type eye; melanosome organization and biogenesis
Research Articles on SHROOM2
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Product Notes
The SHROOM2 shroom2 (Catalog #AAA423288) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-APXL Antibody reacts with Tested: Human; Expected from sequence similarity: Human, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's APXL can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA), Immunohistochemistry (IHC). Peptide ELISA: Antibody detection limit dilution 1: 32000. Immunohistochemistry: In paraffin embedded Human Kidney shows cytoplasm staining in PCT exclusively. Recommended concentration, 4-6ug/ml. Researchers should empirically determine the suitability of the SHROOM2 shroom2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: KCLLDSLQPE RGK. It is sometimes possible for the material contained within the vial of "APXL, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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