Rabbit APPBP2 Polyclonal Antibody | anti-APPBP2 antibody

APPBP2 Antibody

Cat. Num. AAA153397

• Gene Names: APPBP2; PAT1; APP-BP2; HS.84084
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: APPBP2 antibody is affinity chromatography purified via peptide column.
• Synonyms: APPBP2; Polyclonal Antibody; APPBP2 Antibody; PAT1; APP-BP2; HS.84084; KIAA0228; Amyloid protein-binding protein 2; Amyloid beta precursor protein-binding protein 2; amyloid beta precursor protein (cytoplasmic tail) binding protein 2; anti-APPBP2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: APPBP2 antibody is human, mouse and rat reactive. At least two isoforms of APPBP2 are known to exist; this antibody will detect both isoforms.
• Purity/Purification: APPBP2 antibody is affinity chromatography purified via peptide column.
• Form/Format: Liquid
• Concentration: 1 mg/mL (varies by lot)
• Sequence Length: 585

• Applicable Applications for anti-APPBP2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: APPBP2 antibody can be used for detection of APPBP2 by Western blot at 0.5 - 1 mug/ml. Antibody can also be used for Immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
• Conjugate: Unconjugated
• Immunogen: APPBP2 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human APPBP2.
• Buffer: APPBP2 antibody is supplied in PBS containing 0.02% sodium azide.
• Preparation and Storage: APPBP2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.

Western Blot (WB)

(Western blot analysis of APPBP2 in human brain tissue lysate with APPBP2 antibody at (A) 0.5 and (B) 1 μg/ml.)

Immunohistochemistry (IHC)

(Immunohistochemistry of APPBP2 in human brain tissue with APPBP2 antibody at 5 μg/mL.)

Immunofluorescence (IF)

(Immunofluorescence of APPBP2 in human brain tissue with APPBP2 antibody at 20 μg/mL.)

Related Product Information for anti-APPBP2 antibody

The amyloid beta precursor protein (cytoplasmic tail) binding protein 2 (APPBP2), also known as PAT1, interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing (1). The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease (2). APPBP2 has been found to be highly expressed in breast cancer (3).

NCBI and Uniprot Product Information

• NCBI GI #: 18104962
• NCBI GeneID: 10513
• NCBI Accession #: NP_006371
• NCBI GenBank Nucleotide #: NM_006380.3
• UniProt Accession #: Q92624; O95095; Q8WVC9; A8K862
• Molecular Weight: Predicted: 64 kDa; ; Observed: 57 kDa
• NCBI Official Full Name: amyloid protein-binding protein 2 isoform 1
• NCBI Official Synonym Full Names: amyloid beta precursor protein (cytoplasmic tail) binding protein 2
• NCBI Official Symbol: APPBP2
• NCBI Official Synonym Symbols: PAT1; APP-BP2; HS.84084
• NCBI Protein Information: amyloid protein-binding protein 2; protein interacting with APP tail 1
• UniProt Protein Name: Amyloid protein-binding protein 2
• Protein Family: Amyloid protein-binding protein
• UniProt Gene Name: APPBP2
• UniProt Synonym Gene Names: KIAA0228; PAT1; APP-BP2
• UniProt Entry Name: APBP2_HUMAN

NCBI Description

The protein encoded by this gene interacts with microtubules and is functionally associated with beta-amyloid precursor protein transport and/or processing. The beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. The encoded protein may be involved in regulating cell death. This gene has been found to be highly expressed in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Description

APPBP2: May play a role in intracellular protein transport. May be involved in the translocation of APP along microtubules toward the cell surface.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: microtubule; microtubule associated complex; cytoplasmic vesicle membrane; cytoplasm; nucleus

Molecular Function: protein binding; microtubule motor activity

Biological Process: intracellular protein transport; intracellular transport; metabolic process