Rabbit anti-Human ALS Polyclonal Antibody | anti-ALS antibody

ALS Polyclonal Antibody

Cat. Num. AAA9705494

• Gene Names: IGFALS; ALS; ACLSD
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Synonyms: ALS; Polyclonal Antibody; ALS Polyclonal Antibody; Rabbit Anti-ALS Polyclonal Antibody; IGFALS; Insulin-like growth factor-binding protein complex acid labile subunit; anti-ALS antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: ALS Polyclonal Antibody detects endogenous levels of ALS protein.
• Purity/Purification: Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Form/Format: Liquid; PBS Containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 643

• Applicable Applications for anti-ALS antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000; ELISA: 1:10000
• Immunogen: Synthesized peptide derived from the internal region of human ALS at AA rangle: 280-360
• Preparation and Storage: Stable for one year at -20 degree C from date of shipment.; For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Western Blot (WB)

(Fig. Western Blot analysis of CoLo cells using ALS Polyclonal Antibody.)

Related Product Information for anti-ALS antibody

The protein encoded by IGFALS is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.

NCBI and Uniprot Product Information

• NCBI GI #: 225579152
• NCBI GeneID: 3483
• NCBI Accession #: NP_001139478.1
• NCBI GenBank Nucleotide #: NP_001139478.1
• UniProt Accession #: P35858
• NCBI Official Full Name: insulin-like growth factor-binding protein complex acid labile subunit isoform 1
• NCBI Official Synonym Full Names: insulin like growth factor binding protein acid labile subunit
• NCBI Official Symbol: IGFALS
• NCBI Official Synonym Symbols: ALS; ACLSD
• NCBI Protein Information: insulin-like growth factor-binding protein complex acid labile subunit
• UniProt Protein Name: Insulin-like growth factor-binding protein complex acid labile subunit
• Protein Family: Alsin
• UniProt Gene Name: IGFALS
• UniProt Synonym Gene Names: ALS; ALS
• UniProt Entry Name: ALS_HUMAN

NCBI Description

The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Description

IGFALS: Involved in protein-protein interactions that result in protein complexes, receptor-ligand binding or cell adhesion.

Protein type: Cell adhesion; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; extracellular space; extracellular region

Molecular Function: insulin-like growth factor binding

Biological Process: cellular protein metabolic process; signal transduction; cell adhesion

Disease: Acid-labile Subunit Deficiency