Rabbit Akirin1, IN Polyclonal Antibody | anti-AKIRIN1 antibody

Akirin1, IN (C1orf108, chromosome 1 open reading frame 108, FLJ12666, RP11-781D11.2, STRF2, Uncharacterized protein C1orf108)

Cat. Num. AAA619400

• Gene Names: AKIRIN1; STRF2; C1orf108; FLJ12666; RP11-781D11.2
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: Akirin1; IN; Polyclonal Antibody; IN (C1orf108; chromosome 1 open reading frame 108; FLJ12666; RP11-781D11.2; STRF2; Uncharacterized protein C1orf108); Anti -Akirin1; anti-AKIRIN1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Specificity: Recognizes human Akirin1. Species Crossreactivity: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, 0.02% sodium azide.

• Applicable Applications for anti-AKIRIN1 antibody: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.; Dilution: Western Blot: 1-2ug/ml
• Immunogen: Synthetic peptide corresponding to 14aa from near the center of the human Akirin1.
• Positive Control: Rat Liver Tissue Lysate
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(Western blot analysis of Akirin1 in rat liver lysate with Akirin1 antibody at (A) 1 and (B) 2 ug/ml.)

Related Product Information for anti-AKIRIN1 antibody

The highly conserved, nuclear-localized Akirin1 and Akirin2 proteins critically regulate the transcription of NF-kappaB-dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kappaB pathways. Akirin1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.

Product Categories/Family for anti-AKIRIN1 antibody

Antibodies; Abs to Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 210147487
• NCBI GeneID: 79647
• NCBI Accession #: NP_001129747.1
• NCBI GenBank Nucleotide #: NM_001136275.1
• UniProt Accession #: Q6EHZ2; Q9H9L7
• Molecular Weight: 9,604 Da
• NCBI Official Full Name: akirin-1 isoform 2
• NCBI Official Synonym Full Names: akirin 1
• NCBI Official Symbol: AKIRIN1
• NCBI Official Synonym Symbols: STRF2; C1orf108; FLJ12666; RP11-781D11.2
• NCBI Protein Information: akirin-1; OTTHUMP00000008669; OTTHUMP00000232306; OTTHUMP00000232307; OTTHUMP00000232308
• UniProt Protein Name: Putative uncharacterized protein STRF2
• Protein Family: Akirin
• UniProt Gene Name: STRF2
• UniProt Entry Name: Q6EHZ2_HUMAN

Uniprot Description

AKIRIN1: Belongs to the akirin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription regulation

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; nuclear membrane; nucleus