Immunohistochemistry (IHC)
(Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C.)
Rabbit AKIRIN1 Polyclonal Antibody | anti-AKIRIN1 antibody
AKIRIN1 Polyclonal Antibody
Gene Names
AKIRIN1; STRF2; C1orf108
Reactivity
Human, Mouse, Rat, Dog, Horse, Sheep
Applications
Immunohistochemistry
Purity
affinity purified by Protein A
Synonyms
AKIRIN1; Polyclonal Antibody; AKIRIN1 Polyclonal Antibody; AKIRIN 1; C1orf108; FLJ12666; OTTHUMP00000008669; RP11-781D11.2; STRF2; AKIR1_HUMAN; anti-AKIRIN1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat, Dog, Horse, Sheep
Clonality
Polyclonal
Specificity
AKIRIN1 Polyclonal Antibody detects endogenous levels of AKIRIN1 protein.
Purity/Purification
affinity purified by Protein A
Form/Format
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Applicable Applications for anti-AKIRIN1 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:100-500
Immunogen
KLH conjugated synthetic peptide derived from human AKIRIN1:101-192/192
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.
Immunohistochemistry (IHC)
(Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C.)
Immunohistochemistry (IHC)
(Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C.)
Immunohistochemistry (IHC)
(Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C.)
Immunohistochemistry (IHC)
(Paraformaldehyde-fixed, paraffin embedded (rat testis); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (AKIRIN1) Polyclonal Antibody, Unconjugated at 1:200 overnight at 4°C.)
Related Product Information for anti-AKIRIN1 antibody
AKIRIN1 is dispensable in the mouse, and neither knockout mice nor cells derived from them have obvious distinctive phenotypes. In contrast, Akirin2 is required for development in the mouse and knockout of both Akirin homologs in mice show that Akirin2 is required downstream of toll-like receptor (TLR), TNF-alpha and IL-1beta signaling, and for the production of IL-6. Akirin2 is functionally closer to the single gene in Drosophila, as the homozygous null D. melanogaster Akirin mutants show a similar, mid-to-early embryonic death.The highly conserved, nuclear-localized AKIRIN1 and Akirin2 proteins critically regulate the transcription of NF-kB dependent genes and are required for defense against Gram-negative bacteria in the immune deficiency and NF-kB pathways.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
16,497 Da
NCBI Official Synonym Full Names
akirin 1
NCBI Official Symbol
AKIRIN1
NCBI Official Synonym Symbols
STRF2; C1orf108
NCBI Protein Information
akirin-1
UniProt Protein Name
Akirin-1
Protein Family
UniProt Gene Name
AKIRIN1
UniProt Synonym Gene Names
C1orf108
UniProt Entry Name
AKIR1_HUMAN
Uniprot Description
AKIRIN1: Belongs to the akirin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription regulation
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component: nucleoplasm; nuclear membrane; nucleus
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Product Notes
The AKIRIN1 akirin1 (Catalog #AAA3005604) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The AKIRIN1 Polyclonal Antibody reacts with Human, Mouse, Rat, Dog, Horse, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's AKIRIN1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:100-500. Researchers should empirically determine the suitability of the AKIRIN1 akirin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AKIRIN1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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