Immunohistochemistry (IHC)
(Immunochemical staining of human AGXT2 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Rabbit anti-Human AGXT2 Polyclonal Antibody | anti-AGXT2 antibody
Anti-AGXT2 Antibody, Rabbit Polyclonal
Reactivity
Human
Applications
Immunohistochemistry
Purity
Protein A & Antigen Affinity
Synonyms
AGXT2; Polyclonal Antibody; Anti-AGXT2 Antibody; Rabbit Polyclonal; AGXT2 Antibody; Rabbit PAb; Antigen Affinity Purified; Anti-AGT2 Antibody; Anti-DAIBAT Antibody; anti-AGXT2 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
Human AGXT2
Purity/Purification
Protein A & Antigen Affinity
Form/Format
Liquid; PBS, pH7.0 with 0.03% Proclin300
Applicable Applications for anti-AGXT2 antibody
Immunohistochemistry-Paraffin (IHC-P)
Application Notes
IHC-P: 1:200-1:1000
Immunogen
E Coli-derived Human AGXT2 fragment
Conjugation
Unconjugated
Preparation
Produced in rabbits immunized with E Coli-derived Human AGXT2 fragment, and purified by antigen affinity chromatography.
Preparation and Storage
This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.
Immunohistochemistry (IHC)
(Immunochemical staining of human AGXT2 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human AGXT2 in human kidney with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human AGXT2 in human liver with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Immunohistochemistry (IHC)
(Immunochemical staining of human AGXT2 in human liver with rabbit polyclonal antibody at 1:500 dilution, formalin-fixed paraffin embedded sections.)
Related Product Information for anti-AGXT2 antibody
There are two known alanine-glyoxylate aminotransferase (AGXT) isoenzymes in mammals: AGXT1 and AGXT2, both of which catalyze the transfer of an amino group from alanine to glyoxylate. Alanine-glyoxylate aminotransferase 2 (AGXT2) is a multifunctional mitochondrial aminotransferase that functions as a tetramer with a subunit molecular weight of 50-56 kDa. Unlike AGXT1, AGXT2 is localized only in mitochondria in all examined mammalian species. Human AGXT2 is encoded by a nuclear gene located on chromosome 5. After synthesis in the cytoplasm, AGXT2 is transported to mitochondria, where its 41 amino acid N-terminal mitochondrial targeting sequence is cleaved, which leads to formation of the mature form of the enzyme. AGXT2 is primarily expressed in the kidney and liver. Some of the multiple substrates and products of AGXT2 may contribute to the pathogenesis of cardiovascular, renal, neurological and hematological diseases. AGXT2 plays a unique role at the intersection of several key mitochondrial catabolic and anabolic pathways, and it serves as a potential therapeutic drug target.
References
Rodionov RN, et al. (2014) Agxt2: A promiscuous aminotransferase. Trends Pharmacol Sci 35 (11): 575-582.Kittel A, et al. (2014) Alanine-glyoxylate aminotransferase 2 (agxt2) polymorphisms have considerable impact on methylarginine and beta-aminoisobutyrate metabolism in healthy volunteers. PLoS One 9 (2): e88544.Gao Y, et al. (2017) Digenic mutations on scap and agxt2 predispose to premature myocardial infarction. Oncotarget 8 (59): 100141-100149.
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Product Notes
The AGXT2 (Catalog #AAA8110236) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-AGXT2 Antibody, Rabbit Polyclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's AGXT2 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry-Paraffin (IHC-P). IHC-P: 1:200-1:1000. Researchers should empirically determine the suitability of the AGXT2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "AGXT2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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