Rabbit anti-Human LARS2 Polyclonal Antibody | anti-LARS2 antibody

Anti-LARS2 Antibody, Rabbit Polyclonal

Cat. Num. AAA8108658

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A & Antigen Affinity
• Synonyms: LARS2; Polyclonal Antibody; Anti-LARS2 Antibody; Rabbit Polyclonal; LARS2 Antibody; Rabbit PAb; Antigen Affinity Purified; anti-LARS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: Human LARS2
• Purity/Purification: Protein A & Antigen Affinity
• Form/Format: Liquid; PBS, pH7.0 with 0.03% Proclin300

• Applicable Applications for anti-LARS2 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:50-1:200
• Immunogen: E Coli-derived Human LARS2 fragment
• Conjugation: Unconjugated
• Preparation: Produced in rabbits immunized with E Coli-derived Human LARS2 fragment, and purified by antigen affinity chromatography.
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of human LARS2 in human rectum with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Immunohistochemistry (IHC)

(Immunochemical staining of human LARS2 in human urinary bladder with rabbit polyclonal antibody at 1:100 dilution, formalin-fixed paraffin embedded sections.)

Related Product Information for anti-LARS2 antibody

LARS2 is located in the chromosome 3 common eliminated region-1 (C3CER1) at 3p21.3 and encodes mitochondrial leucyl-tRNA synthetase (mtLeuRS), a 903 amino acid protein. This enzyme is important in the production (synthesis) of proteins in cellular structures called mitochondria, the energy-producing centers in cells. Aminoacyl-tRNA synthetases then attach specific amino acids to the 3-ends of their cognate tRNAs, which is required in the cytoplasm and mitochondria for the translation of nuclear and mitochondrial encoded genes, respectively. Apart from two aminoacyl transfer RNA synthases, glycyl-tRNA synthetase and lysyl-tRNA synthetase, all other synthetases are encoded by separate genes for nuclear and mitochondrial functions.

References

Riley LG, et al. (2016) Lars2 variants associated with hydrops, lactic acidosis, sideroblastic anemia, and multisystem failure. JIMD Rep 28 49-57.