Western Blot (WB)
(Western Blot: Sample: Recombinant APC, Mouse.)
Rabbit anti-Mouse Adenomatosis Polyposis Coli Protein (APC) Polyclonal Antibody | anti-APC antibody
Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SGAES KPLIYQMAPP VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKG SSSIKDSKDS KDTHGKQSVG SGSPVQTVGL ETRLNSFVQV EAPEQKGTEA KPGQSNPVSI AETAETCIAE RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST SARPSQIPTP VSTNTKKRDS KTDITESSGA QSPKRHSGSY LVTSV
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant APC, Mouse.)
Western Blot (WB)
(Western Blot: Sample: Recombinant APC, Mouse.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:Mouse Stomach Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:Mouse Stomach Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Mouse Intestine Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:C.Mouse Brain Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:C.Mouse Brain Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:Mouse Liver Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples:Mouse Liver Tissue.)
NCBI and Uniprot Product Information
Uniprot Description
APC: a tumor suppressor. Defects in APC are a cause of familial adenomatous polyposis (FAP). Promotes rapid degradation of CTNNB1 and participates in Wnt signaling. Activity is correlated with its phosphorylation state. Two splice-variant isoforms have been described.
Protein type: Motility/polarity/chemotaxis; Tumor suppressor
Chromosomal Location of Human Ortholog: 18 B1|18 18.53 cM
Cellular Component: axon; axonal growth cone; beta-catenin destruction complex; bicellular tight junction; catenin complex; cell cortex; cell junction; cell projection; cell projection membrane; cell soma; cell-cell adherens junction; centrosome; cytoplasm; cytoplasmic microtubule; cytoskeleton; dendrite; growth cone; kinetochore; lamellipodium; lateral plasma membrane; membrane; microtubule; neuron projection; neuron projection terminus; nuclear membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; Scrib-APC-beta-catenin complex; synapse
Molecular Function: beta-catenin binding; gamma-catenin binding; identical protein binding; microtubule binding; microtubule plus-end binding; protease binding; protein binding; protein complex binding; protein kinase binding; protein kinase regulator activity; ubiquitin protein ligase binding
Biological Process: anterior/posterior pattern specification; axis specification; axonogenesis; canonical Wnt signaling pathway involved in negative regulation of apoptotic process; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; cell cycle arrest; cell migration; cellular response to DNA damage stimulus; chromosome organization and biogenesis; cytoplasmic microtubule organization; dorsal/ventral pattern formation; establishment and/or maintenance of cell polarity; hair follicle development; insulin receptor signaling pathway; kidney development; metaphase/anaphase transition of mitotic cell cycle; mitotic cell cycle spindle assembly checkpoint; mitotic cytokinesis; muscle maintenance; negative regulation of apoptosis; negative regulation of canonical Wnt signaling pathway; negative regulation of cell proliferation; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of epithelial cell proliferation; negative regulation of MAPKKK cascade; negative regulation of microtubule depolymerization; negative regulation of odontogenesis; negative regulation of Wnt signaling pathway; neuron projection development; pattern specification process; positive regulation of apoptosis; positive regulation of cell adhesion; positive regulation of cell death; positive regulation of cell differentiation; positive regulation of cell division; positive regulation of cell migration; positive regulation of epithelial cell differentiation; positive regulation of microtubule polymerization; positive regulation of protein catabolic process; positive regulation of protein localization to centrosome; positive regulation of pseudopodium assembly; protein complex assembly; protein homooligomerization; proximal/distal pattern formation; regulation of attachment of spindle microtubules to kinetochore; regulation of cell cycle; regulation of cell differentiation; regulation of cell migration; regulation of epithelial cell differentiation; regulation of glutamate metabolic process; regulation of microtubule-based process; regulation of nitrogen compound metabolic process; regulation of osteoblast differentiation; regulation of osteoclast differentiation; retina development in camera-type eye; skin development; somatic stem cell maintenance; stem cell maintenance; T cell differentiation in thymus; thymus development; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway
Research Articles on APC
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Product Notes
The APC apc (Catalog #AAA2003060) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Adenomatosis Polyposis Coli Protein (APC) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's Adenomatosis Polyposis Coli Protein (APC) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the APC apc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- SGAES KPLIYQMAPP VSKTEDVWVR IEDCPINNPR SGRSPTGNTP PVIDSVSEKG SSSIKDSKDS KDTHGKQSVG SGSPVQTVGL ETRLNSFVQV EAPEQKGTEA KPGQSNPVSI AETAETCIAE RTPFSSSSSS KHSSPSGTVA ARVTPFNYNP SPRKSSADST SARPSQIPTP VSTNTKKRDS KTDITESSGA QSPKRHSGSY LVTSV. It is sometimes possible for the material contained within the vial of "Adenomatosis Polyposis Coli Protein (APC), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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