Western Blot (WB)
(Western Blot: Sample: Recombinant IGFBP7, Rat.)
Rabbit anti-Rat Insulin Like Growth Factor Binding Protein 7 (IGFBP7) Polyclonal Antibody | anti-IGFBP7 antibody
Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 7 (IGFBP7)
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-KSR KRRKGKAGAA AGGPATLAVC VCKSRYPVCG SDGVTYPSGC QLRAASLRAE SRGEKAITQV SKGTCEQGPS IVTPPKDIWN ITGAKVYLSC EVIGIPTPVL IWNKVKRDHS GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DTGEYECHAS NSQGQASASA KITVVDAIHE IPVKKGEGAQ L
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Recombinant IGFBP7, Rat.)
Western Blot (WB)
(Western Blot: Sample: Recombinant IGFBP7, Rat.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Spleen Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Spleen Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Pancreas Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Pancreas Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Stomach Tissue.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Rat Stomach Tissue.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Uniprot Description
IGFBP7: Binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Defects in IGFBP7 are the cause of retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS). RAMSVPS is an autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction.
Protein type: Secreted, signal peptide; Cell adhesion; Secreted; Cell cycle regulation
Chromosomal Location of Human Ortholog: 4q12
Cellular Component: extracellular matrix; extracellular space; extracellular region
Molecular Function: insulin-like growth factor binding; protein binding
Biological Process: negative regulation of cell proliferation; response to cortisol stimulus; response to retinoic acid; response to heat; regulation of steroid biosynthetic process; regulation of cell growth; cell adhesion; inner ear development; embryo implantation; cellular response to hormone stimulus
Disease: Retinal Arterial Macroaneurysm With Supravalvular Pulmonic Stenosis
Research Articles on IGFBP7
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Product Notes
The IGFBP7 igfbp7 (Catalog #AAA2003027) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 7 (IGFBP7) reacts with Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Insulin Like Growth Factor Binding Protein 7 (IGFBP7) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the IGFBP7 igfbp7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Antigen: The target protein is fused with two N-terminal Tags, His-tag and its sequence is listed below. MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF-KSR KRRKGKAGAA AGGPATLAVC VCKSRYPVCG SDGVTYPSGC QLRAASLRAE SRGEKAITQV SKGTCEQGPS IVTPPKDIWN ITGAKVYLSC EVIGIPTPVL IWNKVKRDHS GVQRTELLPG DRENLAIQTR GGPEKHEVTG WVLVSPLSKE DTGEYECHAS NSQGQASASA KITVVDAIHE IPVKKGEGAQ L. It is sometimes possible for the material contained within the vial of "Insulin Like Growth Factor Binding Protein 7 (IGFBP7), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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