Mouse protein inhibitor of activated STAT, 3 ELISA Kit | PIAS3 elisa kit
Mouse E3 SUMO-protein ligase PIAS3, PIAS3 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
PIAS3: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Monomer. Binds SUMO1 and UBE2I. Interacts with BCL11A, HMGA2, IRF1, MITF and NCOA2. Interacts with STAT5; the interaction occurs on stimulation by PRL. Interacts with GFI1; the interaction relieves the inhibitory effect of PIAS3 on STAT3- mediated transcriptional activity. Interacts with AR, PLAG1 and ZFHX3. Interacts with STAT3; the interaction occurs on stimulation by IL6, CNTF or OSM and inhibits the DNA binding activity of STAT3. By dihydrotestosterone (DHT) in prostate cancer cells. Isoform 1 is expressed in most tissues except thymus and small intestine. Isoform 3 is expressed only in brain, heart, thymus, muscle, lung, testis, lactating breast and embryonic stem cells. Belongs to the PIAS family.
Protein type: EC 6.3.2.-; Nuclear receptor co-regulator; SUMO conjugating system
Cellular Component: dendrite; cytoplasm; synapse; nucleus
Molecular Function: protein C-terminus binding; protein binding; potassium channel regulator activity; enzyme binding; zinc ion binding; coenzyme F420-2 alpha-glutamyl ligase activity; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity; metal ion binding; ribosomal S6-glutamic acid ligase activity; protein N-terminus binding; coenzyme F420-0 gamma-glutamyl ligase activity; SUMO ligase activity; ligase activity
Biological Process: positive regulation of protein sumoylation; protein sumoylation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of membrane potential
Research Articles on PIAS3
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Product Notes
The Mouse PIAS3 pias3 (Catalog #AAA9335126) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9335126 ELISA Kit recognizes Mouse PIAS3. It is sometimes possible for the material contained within the vial of "protein inhibitor of activated STAT, 3, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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