Western Blot (WB)
(Western blot analysis of lysate from mouse kidney tissue, using Hes1 Antibody (Center). MBS9213092 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.)
Rabbit Hes1 Polyclonal Antibody | anti-Hes1 antibody
Mouse Hes1 Antibody (Center)
Western Blot (WB)
(Western blot analysis of lysate from mouse kidney tissue, using Hes1 Antibody (Center). MBS9213092 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.)
Western Blot (WB)
(Western blot analysis of lysate from mouse kidney tissue, using Hes1 Antibody (Center). MBS9213092 was diluted at 1:1000. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20ug.)
Grbavec D.,et al.Eur. J. Biochem. 258:339-349(1998).
Bae S.-K.,et al.Development 127:2933-2943(2000).
NCBI and Uniprot Product Information
Uniprot Description
HES1: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
Protein type: Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor
Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; intracellular; nucleus; chromatin
Molecular Function: protein dimerization activity; JUN kinase binding; protein binding; protein homodimerization activity; DNA binding; sequence-specific DNA binding; chaperone binding; histone deacetylase binding; protein complex binding; chromatin binding; transcription factor activity; transcription factor binding
Biological Process: neural tube development; hindbrain morphogenesis; radial glial cell differentiation in the forebrain; somatic stem cell maintenance; regulation of fat cell differentiation; positive regulation of transcription, DNA-dependent; cell maturation; positive regulation of JAK-STAT cascade; positive regulation of glial cell differentiation; positive regulation of tyrosine phosphorylation of Stat3 protein; midbrain development; protein complex assembly; positive regulation of T cell proliferation; cell adhesion; positive regulation of mitotic cell cycle, embryonic; positive regulation of astrocyte differentiation; positive regulation of DNA binding; cell fate commitment; transcription, DNA-dependent; auditory receptor cell fate determination; hair cell differentiation; regulation of transcription from RNA polymerase II promoter; negative regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription from RNA polymerase II promoter; midbrain-hindbrain boundary morphogenesis; regulation of protein heterodimerization activity; regulation of timing of neuron differentiation; auditory receptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of neurogenesis; regulation of neurogenesis; regulation of transcription, DNA-dependent; pancreas development; positive regulation of cell proliferation; adenohypophysis development; trochlear nerve development; oculomotor nerve development; regulation of timing of cell differentiation; positive regulation of Notch signaling pathway; positive regulation of BMP signaling pathway; STAT protein nuclear translocation; smoothened signaling pathway; Notch signaling pathway; cell migration; thymus development; in utero embryonic development; liver development; pattern specification process; negative regulation of oligodendrocyte differentiation; telencephalon development; negative regulation of cell differentiation; lateral inhibition; pituitary gland development; negative regulation of auditory receptor cell differentiation; neuron morphogenesis during differentiation; artery morphogenesis; lung development
Research Articles on Hes1
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Product Notes
The Hes1 hes1 (Catalog #AAA9213092) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Mouse Hes1 Antibody (Center) reacts with Mouse (Predicted Reactivity: Xenopus, Bovine, Human, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's Hes1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the Hes1 hes1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Hes1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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