Oxidative Stress Induced Growth Inhibitor 1 Recombinant Protein | OSGIN1 recombinant protein

Recombinant Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1)

Cat. Num. AAA2030343

• Gene Names: OSGIN1; BDGI; OKL38
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: >95%
• Synonyms: Oxidative Stress Induced Growth Inhibitor 1; Recombinant Oxidative Stress Induced Growth Inhibitor 1 (OSGIN1); OSGIN1 recombinant protein

• Host: Host: E Coli; Source: Prokaryotic expression
• Purity/Purification: >95%
• Form/Format: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Sequence: The target protein is fused with two N-terminal Tags, His-tag and T7-tag, its sequence is listed below.; GPSGIC LSYLLSGYTP YTKPDAIHPHPLLQRKLTEA PGVSILDQDL DYLSEGLEGR SQSPVALLFD ALLRPDTDFGGNMKSVLTWK HRKEHAIPHV VLGRNLPGGA WHSIEGSMVI LSQGQWMGLPDLEVKDWMQK KRRGLRNSRA TAGDIAHYYR DYVVKKGLGH NFVSGAVVTAVEWGTPDPSS CGAQDSSPLF QVSGFLTRNQ AQQPFSLWAR NVVLATGTFDSPARLGIPGE ALPFIHHELS ALEAATRVGA V
• Sequence Length: 477

• Applicable Applications for OSGIN1 recombinant protein: SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)
• Predicted Molecular Mass: 31.7kDa
• Accurate Molecular Mass (KD): 37kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Tag: two N-terminal Tags, His-tag and T7-tag
• Organism Species: Homo sapiens (Human)
• Fragment: Gly25~Val281
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Preparation and Storage: Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. The loss of this protein is less than 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 33695101
• NCBI GeneID: 29948
• NCBI Accession #: NP_892026.1
• NCBI GenBank Nucleotide #: NM_182981.2
• Molecular Weight: – Da
• NCBI Official Full Name: oxidative stress-induced growth inhibitor 1
• NCBI Official Synonym Full Names: oxidative stress induced growth inhibitor 1
• NCBI Official Symbol: OSGIN1
• NCBI Official Synonym Symbols: BDGI; OKL38
• NCBI Protein Information: oxidative stress-induced growth inhibitor 1
• UniProt Protein Name: Oxidative stress-induced growth inhibitor 1
• Protein Family: Oxidative stress-induced growth inhibitor
• UniProt Gene Name: OSGIN1
• UniProt Synonym Gene Names: OKL38; huOKL38
• UniProt Entry Name: OSGI1_HUMAN

NCBI Description

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

Uniprot Description

OSGIN1: Regulates the differentiation and proliferation of normal cells through the regulation of cell death. Belongs to the OKL38 family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 16q23.3

Molecular Function: growth factor activity

Biological Process: positive regulation of apoptosis; multicellular organismal development; negative regulation of cell growth; cell differentiation