Typical Testing Data/Standard Curve (for reference only)
(Mouse TrkB PicoKine ELISA Kit standard curve )
Mouse TrkB ELISA Kit | NTRK2 elisa kit
Mouse TrkB PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Mouse TrkB PicoKine ELISA Kit standard curve )
Typical Testing Data/Standard Curve (for reference only)
(Mouse TrkB PicoKine ELISA Kit standard curve )
Background: TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene.[1] TrkB is the high affinitycatalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The TrkB receptor is part of the large family of receptor tyrosine kinases. A "tyrosine kinase" is an enzyme which is capable of adding a phosphate group to certain tyrosines on target proteins, or "substrates".Soppet et al. [2]demonstrated that the gp145 gene product of the TRKB gene is rapidly phosphorylated on tyrosine residues upon exposure to BDNF and NTF3. The standard product used in this kit is recombinant TrkB, a 49.5KDa glycoprotein, C32—H439.
NCBI and Uniprot Product Information
Uniprot Description
TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.
Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Trk family
Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; cell; dendrite; postsynaptic density; integral to membrane; dendritic spine; terminal button; excitatory synapse; perikaryon; cytosol; postsynaptic membrane; growth cone; cell soma; membrane; axon; cytoplasm; plasma membrane; presynaptic active zone; intracellular; nerve terminal; receptor complex; endosome
Molecular Function: transferase activity; brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding; protein kinase activity
Biological Process: mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; protein amino acid autophosphorylation; multicellular organismal development; regulation of neurotransmitter secretion; regulation of dendrite development; neuron migration; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; vasculogenesis; cell differentiation; neuromuscular junction development; central nervous system neuron development; nervous system development; regulation of GTPase activity; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system neuron development; positive regulation of phosphoinositide 3-kinase cascade; glutamate secretion; long-term memory; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on NTRK2
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Product Notes
The Mouse NTRK2 ntrk2 (Catalog #AAA175981) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA175981 ELISA Kit recognizes Mouse NTRK2. It is sometimes possible for the material contained within the vial of "TrkB, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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