Neurotrophic Tyrosine Kinase Receptor Type 2/TrkB/NTRK2 Recombinant Protein | TrkB/NTRK2 recombinant protein

Recombinant Mouse Neurotrophic Tyrosine Kinase Receptor Type 2/TrkB/NTRK2 (C-6His)

Cat. Num. AAA2569359

• Gene Names: Ntrk2; Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
• Purity: >95% as determined by reducing SDS-PAGE
• Synonyms: Neurotrophic Tyrosine Kinase Receptor Type 2/TrkB/NTRK2; Recombinant Mouse Neurotrophic Tyrosine Kinase Receptor Type 2/TrkB/NTRK2 (C-6His); BDNF/NT-3 Growth Factors Receptor; GP145-TrkB; Trk-B; Neurotrophic Tyrosine Kinase Receptor Type 2; TrkB Tyrosine Kinase; Tropomyosin-Related Kinase B; NTRK2; TRKB; TrkB/NTRK2 recombinant protein

• Host: Human Cells
• Purity/Purification: >95% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from a 0.2um filtered solution of PBS, pH7.4.
• Sequence: Cys32-His429

• Species: Mouse
• Tag: C-6His
• Endotoxin: <1.0EU per ug as determined by the LAL method.
• Protein Construction: Recombinant Mouse Neurotrophic Tyrosine Kinase Receptor Type 2 is produced by our Mammalian expression system and the target gene encoding Cys32-His429 is expressed with a 6His tag at the C-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for TrkB/NTRK2 recombinant protein

The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.

NCBI and Uniprot Product Information

• NCBI GI #: 136237
• NCBI GeneID: 18212
• UniProt Accession #: P15209; Q3TUF9; Q80WU0; Q91XJ9
• Molecular Weight: 83,744 Da
• NCBI Official Full Name: BDNF/NT-3 growth factors receptor
• NCBI Official Synonym Full Names: neurotrophic tyrosine kinase, receptor, type 2
• NCBI Official Symbol: Ntrk2
• NCBI Official Synonym Symbols: Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
• NCBI Protein Information: BDNF/NT-3 growth factors receptor; trkB tyrosine kinase; neurotrophic tyrosine receptor kinase type 2
• UniProt Protein Name: BDNF/NT-3 growth factors receptor
• UniProt Gene Name: Ntrk2
• UniProt Synonym Gene Names: Trkb; Trk-B
• UniProt Entry Name: NTRK2_MOUSE

Uniprot Description

TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.

Protein type: EC 2.7.10.1; Protein kinase, tyrosine (receptor); Membrane protein, integral; Protein kinase, TK; Kinase, protein; TK group; Trk family

Cellular Component: cell surface; rough endoplasmic reticulum; integral to plasma membrane; cell; dendrite; postsynaptic density; integral to membrane; dendritic spine; terminal button; excitatory synapse; perikaryon; cytosol; postsynaptic membrane; growth cone; cell soma; membrane; axon; cytoplasm; plasma membrane; presynaptic active zone; intracellular; nerve terminal; receptor complex; endosome

Molecular Function: transferase activity; brain-derived neurotrophic factor receptor activity; neurotrophin binding; protein binding; protein homodimerization activity; ephrin receptor binding; brain-derived neurotrophic factor binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; transmembrane receptor protein tyrosine kinase activity; neurotrophin receptor activity; ATP binding; protein kinase activity

Biological Process: mechanoreceptor differentiation; peptidyl-tyrosine phosphorylation; retinal rod cell development; protein amino acid autophosphorylation; multicellular organismal development; regulation of neurotransmitter secretion; regulation of dendrite development; neuron migration; positive regulation of synaptic transmission, glutamatergic; protein amino acid phosphorylation; neuron differentiation; positive regulation of MAPKKK cascade; positive regulation of cell proliferation; oligodendrocyte differentiation; feeding behavior; negative regulation of neuron apoptosis; regulation of metabolic process; vasculogenesis; cell differentiation; neuromuscular junction development; central nervous system neuron development; nervous system development; regulation of GTPase activity; brain-derived neurotrophic factor receptor signaling pathway; regulation of protein kinase B signaling cascade; learning; positive regulation of peptidyl-serine phosphorylation; peripheral nervous system neuron development; positive regulation of phosphoinositide 3-kinase cascade; glutamate secretion; long-term memory; regulation of MAPKKK cascade; positive regulation of axonogenesis; cerebral cortex development; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway