Mouse Nuclear factor NF-kappa-B p100 subunit ELISA Kit | Nfkb2 elisa kit

Mouse Nuclear factor NF-kappa-B p100 subunit ELISA Kit

Cat. Num. AAA289429

• Gene Names: Nfkb2; lyt; p49; p52; p50B; p49/p100; NF-kappaB2
• Reactivity: Mouse
• Synonyms: Nuclear factor NF-kappa-B p100 subunit; Mouse Nuclear factor NF-kappa-B p100 subunit ELISA Kit; DNA-binding factor KBF2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Nfkb2; Nfkb2 elisa kit

• Reactivity: Mouse
• Sequence Length: 899

• Assay Type: Sandwich
• Detection Range: 0.156-10 ng/mL
• Sensitivity: 0.083 ng/mL
• Intra-Assay CV: <=9.0%
• Inter-Assay CV: <=11.1%
• Recovery: 89%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 293651546
• NCBI GeneID: 18034
• NCBI Accession #: NP_001170840.1
• NCBI GenBank Nucleotide #: NM_001177369.1
• UniProt Accession #: Q9WTK5
• Molecular Weight: 96,832 Da
• NCBI Official Full Name: nuclear factor NF-kappa-B p100 subunit isoform a
• NCBI Official Synonym Full Names: nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100
• NCBI Official Symbol: Nfkb2
• NCBI Official Synonym Symbols: lyt; p49; p52; p50B; p49/p100; NF-kappaB2
• NCBI Protein Information: nuclear factor NF-kappa-B p100 subunit
• UniProt Protein Name: Nuclear factor NF-kappa-B p100 subunit
• Protein Family: Nuclear factor
• UniProt Gene Name: Nfkb2
• UniProt Entry Name: NFKB2_MOUSE

Uniprot Description

NFkB-p100: a transcription factor of the nuclear factor-kappaB ( NFkB) group. Precursor of the p52 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. LT-beta receptor agonists and LPS induce NF-kappaB/p100 processing to p52 at the level of the ribosome. There are five NFkB proteins in mammals (RelA/NFkB-p65, RelB, c-Rel, NF-_B1/NFkB-p105, and NF-_B2/NFkB-p100). They form a variety of homodimers and heterodimers, each of which activates its own characteristic set of genes. Two spliced isoforms have been identified. Isoform p49 is a subunit of the NF-kappa-B protein complex, which stimulates the HIV enhancer in synergy with p65.

Protein type: DNA-binding; Oncoprotein; Transcription factor

Cellular Component: Bcl3/NF-kappaB2 complex; cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: chromatin binding; DNA binding; protein binding; transcription factor activity

Biological Process: extracellular matrix organization and biogenesis; follicular dendritic cell differentiation; germinal center formation; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; lymph node development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to cytokine stimulus; rhythmic process; signal transduction; spleen development; transcription from RNA polymerase II promoter; transcription, DNA-dependent