Typical Testing Data/Standard Curve (for reference only)
Mouse Neurofibromin ELISA Kit | Nf1 elisa kit
Mouse Neurofibromin ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
Typical Testing Data/Standard Curve (for reference only)
NCBI and Uniprot Product Information
Uniprot Description
NF1: a Ras-GAP, highly expressed in developing neural cells. Possesses tumor suppressor activity, presumably by virtue of its GTPase activating domain. Neurofibromin is phosphorylated in response to EGF in CNS cells and cell lines. Defects in NF1 are the cause of type 1 neurofibromatosis (NF1), Watson syndrome, and familial spinal neurofibromatosis. NF1 is one of the most frequent autosomal dominant diseases. Four alternatively spliced isoforms have been described.
Protein type: Motility/polarity/chemotaxis; GAPs; Nucleolus; GAPs, Ras; Tumor suppressor
Cellular Component: axon; cytoplasm; dendrite; membrane; neuron projection; nucleus; postsynaptic density; protein complex
Molecular Function: GTPase activator activity; lipid binding; microtubule binding; phosphatidylcholine binding; phosphatidylethanolamine binding; protein binding; syndecan binding
Biological Process: actin cytoskeleton organization and biogenesis; adrenal gland development; amygdala development; artery morphogenesis; brain development; camera-type eye morphogenesis; cell communication; cerebral cortex development; cognition; collagen fibril organization; extracellular matrix organization and biogenesis; forebrain astrocyte development; forebrain morphogenesis; heart development; induction of apoptosis via death domain receptors; liver development; MAPKKK cascade; metanephros development; myelination in the peripheral nervous system; negative regulation of angiogenesis; negative regulation of astrocyte differentiation; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of cell-matrix adhesion; negative regulation of endothelial cell proliferation; negative regulation of fibroblast proliferation; negative regulation of MAP kinase activity; negative regulation of MAPKKK cascade; negative regulation of neuroblast proliferation; negative regulation of neurotransmitter secretion; negative regulation of oligodendrocyte differentiation; negative regulation of osteoclast differentiation; negative regulation of protein kinase activity; negative regulation of Rac protein signal transduction; negative regulation of Ras protein signal transduction; negative regulation of transcription factor import into nucleus; neural tube development; osteoblast differentiation; peripheral nervous system development; phosphoinositide 3-kinase cascade; pigmentation; positive regulation of adenylate cyclase activity; positive regulation of apoptosis; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of neuron apoptosis; Ras protein signal transduction; regulation of angiogenesis; regulation of blood vessel endothelial cell migration; regulation of bone resorption; regulation of cell proliferation; regulation of cell-matrix adhesion; regulation of gene expression; regulation of glial cell differentiation; regulation of GTPase activity; regulation of long-term neuronal synaptic plasticity; regulation of MAPKKK cascade; regulation of neuron differentiation; regulation of synaptic transmission, GABAergic; response to hypoxia; Schwann cell development; signal transduction; skeletal muscle development; smooth muscle development; spinal cord development; sympathetic nervous system development; visual learning; wound healing
Research Articles on Nf1
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Product Notes
The Mouse Nf1 nf1 (Catalog #AAA2881149) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2881149 ELISA Kit recognizes Mouse Nf1. It is sometimes possible for the material contained within the vial of "Neurofibromin, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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