COBRA1 Blocking Peptide | NELFB blocking peptide

COBRA1 Antibody (Center) Blocking Peptide

• Gene Names: NELFB; COBRA1; NELF-B
• Synonyms: COBRA1; COBRA1 Antibody (Center) Blocking Peptide; Negative elongation factor B; NELF-B; Cofactor of BRCA1; NELFB; KIAA1182; NELFB blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 580

• Cellular Location: Nucleus.
• Tissue Location: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for NELFB blocking peptide

Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding.

NCBI and Uniprot Product Information

• NCBI GI #: 38372378
• NCBI GeneID: 25920
• UniProt Accession #: Q8WX92; Q96EW5; Q9H9R4; Q9ULN8; Q9Y3W0; A2BFA3
• Molecular Weight: 65,697 Da
• NCBI Official Full Name: Negative elongation factor B
• NCBI Official Synonym Full Names: negative elongation factor complex member B
• NCBI Official Symbol: NELFB
• NCBI Official Synonym Symbols: COBRA1; NELF-B
• NCBI Protein Information: negative elongation factor B
• UniProt Protein Name: Negative elongation factor B
• UniProt Gene Name: NELFB
• UniProt Synonym Gene Names: COBRA1; KIAA1182; NELF-B
• UniProt Entry Name: NELFB_HUMAN

NCBI Description

NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]

Uniprot Description

COBRA1: a subunit of the multisubunit transcription elongation factor NELF (negative elongation factor). May be involved in transcriptional pausing of RNA polymerase II (RNAPII). Interacts with the first BRCT repeat of BRCA1.

Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 9q34

Cellular Component: cytoplasm; nucleoplasm

Molecular Function: protein binding

Biological Process: positive regulation of viral transcription; RNA elongation from RNA polymerase II promoter; transcription from RNA polymerase II promoter