NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
Uniprot Description
MUC17: Probably plays a role in maintaining homeostasis on mucosal surfaces. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: apical plasma membrane; external side of plasma membrane; extracellular region; Golgi lumen; integral to membrane; microvillus
Molecular Function: extracellular matrix constituent, lubricant activity; PDZ domain binding; protein binding
Biological Process: cellular homeostasis; cellular protein metabolic process; O-glycan processing; post-translational protein modification; protein amino acid O-linked glycosylation
Research Articles on MUC17
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Product Notes
The Human MUC17 muc17 (Catalog #AAA2881010) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA2881010 ELISA Kit recognizes Human MUC17. It is sometimes possible for the material contained within the vial of "Mucin-17, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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