Mouse anti-Human Lamin A/C Antibody
Lamin A/C Antibody [JOL2]: Biotin
Reactivity
Human
Applications
Immunoprecipitation, Flow Cytometry, Functional Assay, Western Blot, Immunohistochemistry
Purity
Protein G
Synonyms
Lamin A/C; Lamin A/C Antibody [JOL2]: Biotin; anti-Lamin A/C antibody
Host
Mouse
Reactivity
Human
Isotype
IgG1
Clone Number
JOL2
Specificity
This antibody reacts with both recombinant and native Lamin A and C in humans.It has been shown to bind to an epitope between amino acids 464-572
Purity/Purification
Protein G
Form/Format
Purified IgG conjugated to Biotin using Innova Biosciences LightningLink®, supplied in Phosphate buffered saline (PBS) containing 0.09% Sodium azide
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-Lamin A/C antibody
Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes
Optimal antibody dilution should be determined by titration, however as a guideline try at 4µg/ml for IHC (P)
Immunogen
Recombinant human lamin A
Myeloma/Fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP2-0/Ag4 myeloma cell line
References
Bensalah M et al. Combined methods to evaluate human cells in muscle xenografts. PLoS One 14:e0211522 (2019).PubMed: 31048846Osmanagic-Myers S et al. Endothelial progerin expression causes cardiovascular pathology through an impaired mechanoresponse. J Clin Invest 129:531-545 (2019).
Tiwari A et al. Stress-Induced Phosphorylation of Nuclear YB-1 Depends on Nuclear Trafficking of p90 Ribosomal S6 Kinase. Int J Mol Sci 19:N/A (2018).PubMed: 30126195Borroni AP et al. Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin. Aging Cell 17:N/A (2018). WB ; Human .
Tiwari A et al. Stress-Induced Phosphorylation of Nuclear YB-1 Depends on Nuclear Trafficking of p90 Ribosomal S6 Kinase. Int J Mol Sci 19:N/A (2018).PubMed: 30126195Borroni AP et al. Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin. Aging Cell 17:N/A (2018). WB ; Human .
NCBI and Uniprot Product Information
UniProt Accession #
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Product Notes
The Lamin A/C (Catalog #AAA375430) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Lamin A/C Antibody [JOL2]: Biotin reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Lamin A/C can be used in a range of immunoassay formats including, but not limited to, Immunoprecipitation (IP), Flow Cytometry (FC/FACS), Western Blot (WB), Immunohistochemistry (IHC). Optimal antibody dilution should be determined by titration, however as a guideline try at 4µg/ml for IHC (P). Researchers should empirically determine the suitability of the Lamin A/C for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lamin A/C, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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