Mouse anti-Human CD28 Antibody | anti-CD28 antibody
CD28 PE
Gene Names
CD28; Tp44
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
Protein A/G Chromatography
Synonyms
CD28; CD28 PE; anti-CD28 antibody
Host
Mouse
Reactivity
Human
Isotype
IgG1
Clone Number
B-23
Purity/Purification
Protein A/G Chromatography
Form/Format
Provided as sterile filtered solution in phosphate buffered saline with 0.08% sodium azide and 0.2% carrier protein
Sequence Length
123
Applicable Applications for anti-CD28 antibody
Flow Cytometry (FC/FACS)
Immunogen
CD28=Derived from the hybridization of mouse Sp2/O-Ag14 myeloma cells with spleen cells of BALB/c mice immunized with the HPB-ALL T-cell line.
Preparation and Storage
Product should be stored at 4-8 degree C. DO NOT FREEZE
Related Product Information for anti-CD28 antibody
Anti-human CD28 binds the 44kDa MW cell surface protein on the surface of most T cells. CD28 acts as the ligand for the B7/BB-1 molecule on the surface of activated B cells. B7/BB-1 costimulates T cells through CD28, along with CD2 and CD3.CD28 antigen is a disulfide-linked homodimeric glycoprotein. The CD28 antigen is present on approximately 60%-80% T lymphocytes (95% of CD4 and 50% of CD8 lymphocytes). CD28 regulates the expression of cytokines by T cells, not only IL-2, but also IL-1 alpha and CSF-1, usually synthesized by accessory cells. CD28 functions as a cell adhesion molecule (CAM) for certain T cell subsets.
Product Categories/Family for anti-CD28 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
25,066 Da
NCBI Official Full Name
T-cell-specific surface glycoprotein CD28 isoform 2
NCBI Official Synonym Full Names
CD28 molecule
NCBI Official Symbol
CD28
NCBI Official Synonym Symbols
Tp44
NCBI Protein Information
T-cell-specific surface glycoprotein CD28; CD28 antigen
UniProt Protein Name
T-cell-specific surface glycoprotein CD28
Protein Family
UniProt Gene Name
CD28
UniProt Entry Name
CD28_HUMAN
NCBI Description
The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Description
Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.
Subunit structure: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Ref.13
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells.
Sequence similarities: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Research Articles on CD28
Similar Products
Product Notes
The CD28 cd28 (Catalog #AAA396663) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD28 PE reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD28 can be used in a range of immunoassay formats including, but not limited to, Flow Cytometry (FC/FACS). Researchers should empirically determine the suitability of the CD28 cd28 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD28, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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