Testing Data
(Lane 1 - JurkatLane 2 - NIH 3T3Total cell lysates were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3alpha-HRP. Proteins were visualized using chemiluminescent detection.)
Mouse GSK-3 alpha Antibody | anti-GSK-3alpha antibody
Mouse Anti-GSK-3alpha-HRP
Applications
Western Blot, Immunoprecipitation
Synonyms
GSK-3 alpha; Mouse Anti-GSK-3alpha-HRP; Glycogen synthase kinase-3 alpha; anti-GSK-3alpha antibody
Host
Mouse
Isotype
IgG2a
Clone Number
SBGSK3a4
Specificity
Human/Mouse GSK-3alpha
Form/Format
Supplied in a stock solution of 50% glycerol/50% PBS, pH 7.4; No preservative added
Applicable Applications for anti-GSK-3alpha antibody
Western Blot (WB), Immunoprecipitation (IP)
Immunogen
Recombinant N-terminal GSK-3alpha
Conjugation
HRP (Horseradish Peroxidase)
Preparation and Storage
Store at 2-8 degree C.
Testing Data
(Lane 1 - JurkatLane 2 - NIH 3T3Total cell lysates were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3alpha-HRP. Proteins were visualized using chemiluminescent detection.)
Testing Data
(Lane 1 - JurkatLane 2 - NIH 3T3Total cell lysates were resolved by electrophoresis, transferred to PVDF membrane, and probed with Mouse Anti-GSK-3alpha-HRP. Proteins were visualized using chemiluminescent detection.)
Related Product Information for anti-GSK-3alpha antibody
Glycogen synthase kinase-3 (GSK-3) is a protein serine kinase that phosphorylates glycogen synthase and thereby inactivates it. Insulin stimulates the dephosphorylation of glycogen synthase at the sites phosphorylated by GSK-3 and subsequently inhibits GSK-3 acutely leading to the stimulation of glycogen synthesis. GSK-3 signaling is performed by two isoforms, GSK-3alpha and GSK-3beta. The two isoforms share 97% sequence similarity within their catalytic domains. GSK-3 has also been shown to play a role in protein synthesis, cell adhesion, cell proliferation, cell differentiation, microtubule dynamics, and cell motility.
References
1. Meares GP, Zmijewska AA, Jope RS. HSP105 interacts with GRP78 and GSK3 and promotes ER stress-induced caspase-3 activation. Cell Signal. 2008;20:347-58. (IP)
2. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (IP)
2. Sun M, Song L, Li Y, Zhou T, Jope RS. Identification of an antiapoptotic protein complex at death receptors. Cell Death Differ. 2008;15:1887-1900. (IP)
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Product Notes
The GSK-3alpha (Catalog #AAA679337) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GSK-3 alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). Researchers should empirically determine the suitability of the GSK-3alpha for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GSK-3 alpha, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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