Typical Testing Data/Standard Curve (for reference only)
(Mouse TEK/TIE2 PicoKine ELISA Kit standard curve )
Mouse TEK/TIE2 ELISA Kit | TEK elisa kit
Mouse TEK/TIE2 PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Mouse TEK/TIE2 PicoKine ELISA Kit standard curve )
Typical Testing Data/Standard Curve (for reference only)
(Mouse TEK/TIE2 PicoKine ELISA Kit standard curve )
Background: Angiopoietin-1 receptor, also called TEK or TIE2 is a protein that in humans is encoded by the TEK gene. This gene is mapped to 9p21.2. The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations, the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
NCBI and Uniprot Product Information
Uniprot Description
TIE2: a receptor tyrosine kinase of the Tie family. Receptor for angiopoietin 1. Expressed almost exclusively in endothelial cells. May constitute the earliest mammalian endothelial cell lineage marker. Appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.
Protein type: Kinase, protein; Membrane protein, integral; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Protein kinase, TK; TK group; Tie family
Cellular Component: microvillus; cell surface; integral to plasma membrane; basolateral plasma membrane; extracellular region; integral to membrane; actin filament; intercellular junction; lipid raft; cytoskeleton; membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; basal plasma membrane; stress fiber; plasma membrane; cell junction
Molecular Function: transferase activity; protein binding; protein-tyrosine kinase activity; growth factor binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; receptor activity; transmembrane receptor protein tyrosine kinase activity; ATP binding; protein kinase activity
Biological Process: positive regulation of cell adhesion; peptidyl-tyrosine phosphorylation; heart development; protein amino acid autophosphorylation; cell-matrix adhesion; positive regulation of cytokine secretion during immune response; protein amino acid phosphorylation; regulation of cell migration; positive regulation of vascular endothelial growth factor receptor signaling pathway; cell-cell adhesion; positive regulation of focal adhesion formation; hemopoiesis; angiogenesis; vasculogenesis; Tie receptor signaling pathway; regulation of endothelial cell proliferation; response to retinoic acid; regulation of establishment and/or maintenance of cell polarity; positive regulation of phosphoinositide 3-kinase activity; regulation of angiogenesis; positive regulation of peptidyl-serine phosphorylation; protein oligomerization; positive regulation of phosphoinositide 3-kinase cascade; patterning of blood vessels; positive regulation of protein kinase B signaling cascade; negative regulation of angiogenesis; positive regulation of angiogenesis; positive regulation of protein import into nucleus; response to estrogen stimulus; endothelial cell proliferation; positive regulation of protein amino acid phosphorylation; sprouting angiogenesis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis
Research Articles on TEK
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Product Notes
The Mouse TEK tek (Catalog #AAA177220) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA177220 ELISA Kit recognizes Mouse TEK. It is sometimes possible for the material contained within the vial of "TEK/TIE2, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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