Mouse ICOS/Inducible T-Cell Costimulator ELISA Kit | ICOS elisa kit

Mouse ICOS/Inducible T-Cell Costimulator ELISA Kit

Cat. Num. AAA2890778

• Gene Names: Icos; H4; CCLP; AILIM; CRP-1; Ly115
• Reactivity: Mouse
• Synonyms: ICOS/Inducible T-Cell Costimulator; Mouse ICOS/Inducible T-Cell Costimulator ELISA Kit; Inducible T-cell costimulator; Activation-inducible lymphocyte immunomediatory molecule; CD28 and CTLA-4-like protein; CCLP; CD28-related protein 1; CRP-1; CD278; Ailim; ICOS elisa kit

• Reactivity: Mouse
• Specificity: Recombinant and natural Mouse Inducible T-cell costimulator
• Sequence Length: 200

• Samples: Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids
• Detection Range: 0.78-50 ng/mL
• Sensitivity: < 0.29 ng/mL
• Intra-assay Precision: <=5.1%
• Inter-assay Precision: <=9.2%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

Related Product Information for ICOS elisa kit

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation specific for target antigen and then avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. Then a TMB substrate solution is added to each well. Only those wells that contain target antigen, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of a sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450 nm +/- 2 nm. The concentration of target antigen in the samples is then determined by comparing the O.D. of the samples to the standard curve.

NCBI and Uniprot Product Information

• NCBI GI #: 224809335
• NCBI GeneID: 54167
• NCBI Accession #: NP_059508.2
• NCBI GenBank Nucleotide #: NM_017480.2
• UniProt Accession #: Q9WVS0
• NCBI Official Full Name: inducible T-cell costimulator
• NCBI Official Synonym Full Names: inducible T cell co-stimulator
• NCBI Official Symbol: Icos
• NCBI Official Synonym Symbols: H4; CCLP; AILIM; CRP-1; Ly115
• NCBI Protein Information: inducible T-cell costimulator
• UniProt Protein Name: Inducible T-cell costimulator
• Protein Family: Inducible T-cell costimulator
• UniProt Gene Name: Icos
• UniProt Synonym Gene Names: Ailim; CCLP; CRP-1

Uniprot Description

Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes ().