Mouse FIG4 homolog (S. cerevisiae) ELISA Kit | FIG4 elisa kit
Mouse Polyphosphoinositide phosphatase, FIG4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
SAC3: The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes. Defects in FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J). CMT4J is a recessive demyelinating, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies characterized by severely reduced motor nerve conduction velocities (NCVs) (less than 38m/s) and segmental demyelination and remyelination, and primary peripheral axonal neuropathies characterized by normal or mildly reduced NCVs and chronic axonal degeneration and regeneration on nerve biopsy. Defects in FIG4 are the cause of amyotrophic lateral sclerosis type 11 (ALS11). ALS is a neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10%.
Protein type: EC 3.1.3.-
Cellular Component: Golgi apparatus; recycling endosome; membrane; endoplasmic reticulum; endosome membrane; endosome
Molecular Function: protein tyrosine/threonine phosphatase activity; phosphatidylinositol-3-phosphatase activity; inositol-1,3,4-trisphosphate 4-phosphatase activity; phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity; hydrolase activity; inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity; inositol bisphosphate phosphatase activity; inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity; phosphoric ester hydrolase activity; transmembrane receptor protein phosphatase activity; JUN kinase phosphatase activity; 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity; NADP phosphatase activity; phosphatidylinositol-4-phosphate phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; inositol-4,5-bisphosphate 5-phosphatase activity; phosphohistidine phosphatase activity; MAP kinase tyrosine/serine/threonine phosphatase activity
Biological Process: myelin formation; negative regulation of myelination; pigmentation; dephosphorylation; neuron development; locomotory behavior; phosphatidylinositol metabolic process; vacuole organization and biogenesis
Research Articles on FIG4
Similar Products
Product Notes
The Mouse FIG4 fig4 (Catalog #AAA9338853) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9338853 ELISA Kit recognizes Mouse FIG4. It is sometimes possible for the material contained within the vial of "FIG4 homolog (S. cerevisiae), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
