Typical Testing Data/Standard Curve (for reference only)
(Mouse CD40/TNFRSF5 PicoKine ELISA Kit standard curve )
Mouse CD40/TNFRSF5 ELISA Kit | CD40 elisa kit
Mouse CD40/TNFRSF5 PicoKine ELISA Kit
Typical Testing Data/Standard Curve (for reference only)
(Mouse CD40/TNFRSF5 PicoKine ELISA Kit standard curve )
Typical Testing Data/Standard Curve (for reference only)
(Mouse CD40/TNFRSF5 PicoKine ELISA Kit standard curve )
Background: CD40 is a cell surface receptor that is expressed on the surface of all mature B cells, most mature B-cell malignancies, and some early B-cell acute lymphocytic leukemias, but is not expressed on plasma cells.1The CD40gene is localized to the long arm of chromosome 20, bands q12-q13.2.2The protein encoded by this gene is amember of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.3
NCBI and Uniprot Product Information
Uniprot Description
CD40: a member of the TNF-receptor superfamily. This receptor for CD40L mediates a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. Defects in CD40 are the cause of hyper-IgM immunodeficiency type 3 (HIGM3). HIGM3 is an autosomal recessive disorder which includes an inability of B cells to undergo isotype switching, one of the final differentiation steps in the humoral immune system, an inability to mount an antibody-specific immune response, and a lack of germinal center formation. Two alternatively spliced isoforms have been reported. Isoform I is a type I membrane protein; isoform II is secreted.
Protein type: Membrane protein, integral; Receptor, cytokine
Cellular Component: extracellular space; cell surface; membrane; intracellular membrane-bound organelle; cell; cytoplasm; plasma membrane; integral to membrane; extracellular region; external side of plasma membrane
Molecular Function: protein binding; enzyme binding; ubiquitin protein ligase binding; antigen binding
Biological Process: positive regulation of isotype switching to IgG isotypes; regulation of immune response; B cell activation; immune system process; positive regulation of interleukin-12 production; immune response-regulating cell surface receptor signaling pathway; activation of NF-kappaB transcription factor; cellular calcium ion homeostasis; positive regulation of MAP kinase activity; positive regulation of tyrosine phosphorylation of Stat1 protein; positive regulation of B cell proliferation; protein kinase B signaling cascade; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; inflammatory response; defense response to virus; regulation of immunoglobulin secretion
Research Articles on CD40
Similar Products
Product Notes
The Mouse CD40 cd40 (Catalog #AAA175879) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA175879 ELISA Kit recognizes Mouse CD40. It is sometimes possible for the material contained within the vial of "CD40/TNFRSF5, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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