Immunohistochemistry (IHC)
(Paraffin embedded human gastric cancer tissue was stained with Mouse IgG1-UNLB isotype control (MBS679010) (left) and Mouse Anti-Human MMP-2-UNLB (MBS670150) (right) followed by HRP conjugated Anti-Mouse Ig secondary antibody, DAB, and hematoxylin. )
anti-Human MMP-2 Antibody | anti-Mmp2 antibody
Mouse Anti-Human MMP-2-UNLB
Gene Names
Mmp2; Mmp2
Reactivity
Human
Applications
ELISA
Synonyms
MMP-2; Mouse Anti-Human MMP-2-UNLB; Matrix metalloproteinase 2; gelatinase A; 72 kDa type IV collagenase; anti-Mmp2 antibody
Host
Mouse (BALB/c)
Reactivity
Human
Isotype
IgG1 kappa
Clone Number
SB13a
Specificity
Human MMP-2
Form/Format
The purified antibody (UNLB) is supplied as 0.1 mg purified immunoglobulin in 0.2 mL of borate buffered saline, pH 8.2.
No preservatives or amine-containing buffer salts added.
No preservatives or amine-containing buffer salts added.
Sequence Length
30
Applicable Applications for anti-Mmp2 antibody
ELISA
Application Notes
ELISA: < 1 ug/mL
Since applications vary, you should determine the optimum working dilution for the product that is appropriate for your specific need.
Since applications vary, you should determine the optimum working dilution for the product that is appropriate for your specific need.
Immunogen
Recombinant MMP-2
Preparation and Storage
Store at 2-8°C.
Immunohistochemistry (IHC)
(Paraffin embedded human gastric cancer tissue was stained with Mouse IgG1-UNLB isotype control (MBS679010) (left) and Mouse Anti-Human MMP-2-UNLB (MBS670150) (right) followed by HRP conjugated Anti-Mouse Ig secondary antibody, DAB, and hematoxylin. )
Immunohistochemistry (IHC)
(Paraffin embedded human gastric cancer tissue was stained with Mouse IgG1-UNLB isotype control (MBS679010) (left) and Mouse Anti-Human MMP-2-UNLB (MBS670150) (right) followed by HRP conjugated Anti-Mouse Ig secondary antibody, DAB, and hematoxylin. )
Related Product Information for anti-Mmp2 antibody
Matrix metalloproteinases (MMPs) are a family of at least 23 structurally related, zinc-containing enzymes that have the ability to breakdown connective tissue. MMP-2, along with MMP-9, belongs to the gelatinase group of MMP’s which have three repeats of a type II fibronectin domain inserted in the catalytic domain. MMP-2 has shown substrate specificity to collagens types I, II, and III as well as the extracellular matrix component aggrecan.
References
1. Steffensen, B., U.M. Wallon, and C.M. Overall. 1995. J. Biol. Chem. 270:11555.
2. Collier, I.E., S.M. Wilhelm, A.Z. Eisen, B.L. Marmer, G.A. Grant, J.L. Seltzer, A. Kronberger, C. He, E.A. Bauer, and G.L. Goldberg. 1988. J. Biol. Chem. 263:6579.
3. Allan, J.A., A.J. Docherty, P.J. Barker, N.S. Huskisson, J.J. Reynolds, and G. Murphy. 1995. Biochem. J. 309:229.
4. Seltzer, J.L., A.Z. Eisen, E.A. Bauer, N.P. Morris, R.W. Glanville, and R.E. Burgeson. 1989. J. Biol. Chem. 264:3822.
5. Aimes, R.T., and J.P. Quigley. 1995. J. Biol. Chem. 270:5872.
6. Murphy, G., M.I. Cockett, R.V. Ward, and A.J. Docherty. 1991. Biochem. J. 277:277.
7. Welgus, H.G., C.J. Fliszar, J.L. Seltzer, T.M. Schmid, and J.J. Jeffery. 1990. J. Biiol. Chem. 265:13521.
8. Sires, U.I., B. Dublet, E. Aubert-Foucher, M. van der Rest, and G.G. Welgus. 1995. J. Biol. Chem. 270:1062.
9. Senior, R.M., G.L. Griffin, C.J. Fliszar, S.D. Shapiro, G.I. Goldberg, and H.G. Welgus. 1991. J. Biol. Chem. 266:7870.
10. Khan, K.M., G.W. Laurie, T.A. McCaffrey, and D.J. Falcone. 2002. J. Biol. Chem. 277:13778.
11. Giannelli, G., J. Falk-Marzillier, O. Schiraldi, W.G. Stetler-Stevenson, and V. Quaranta. 1997. Science 277:225.
12. Chandler, S., R. Coates, A. Gearing, J. Lury, G. Wells, and E. Bone. 1995. Neurosci. Lett. 201:223.
13. Crabbe, T., J.P. O'Connell, B.J. Smith, and A.J. Docherty. 1994. Biochemistry 33:14419.
14. Fridman, R., M. Toth, D. Pena, and S. Mobashery. 1995. Cancer Res. 55:2548.
15. Knauper, V., H. Will, C. Lopez-Otin, B. Smith, S.J. Atkinson, H. Stanton, R.M. Hembry, and G. Murphy. 1996. J. Biol. Chem. 271:17124.
2. Collier, I.E., S.M. Wilhelm, A.Z. Eisen, B.L. Marmer, G.A. Grant, J.L. Seltzer, A. Kronberger, C. He, E.A. Bauer, and G.L. Goldberg. 1988. J. Biol. Chem. 263:6579.
3. Allan, J.A., A.J. Docherty, P.J. Barker, N.S. Huskisson, J.J. Reynolds, and G. Murphy. 1995. Biochem. J. 309:229.
4. Seltzer, J.L., A.Z. Eisen, E.A. Bauer, N.P. Morris, R.W. Glanville, and R.E. Burgeson. 1989. J. Biol. Chem. 264:3822.
5. Aimes, R.T., and J.P. Quigley. 1995. J. Biol. Chem. 270:5872.
6. Murphy, G., M.I. Cockett, R.V. Ward, and A.J. Docherty. 1991. Biochem. J. 277:277.
7. Welgus, H.G., C.J. Fliszar, J.L. Seltzer, T.M. Schmid, and J.J. Jeffery. 1990. J. Biiol. Chem. 265:13521.
8. Sires, U.I., B. Dublet, E. Aubert-Foucher, M. van der Rest, and G.G. Welgus. 1995. J. Biol. Chem. 270:1062.
9. Senior, R.M., G.L. Griffin, C.J. Fliszar, S.D. Shapiro, G.I. Goldberg, and H.G. Welgus. 1991. J. Biol. Chem. 266:7870.
10. Khan, K.M., G.W. Laurie, T.A. McCaffrey, and D.J. Falcone. 2002. J. Biol. Chem. 277:13778.
11. Giannelli, G., J. Falk-Marzillier, O. Schiraldi, W.G. Stetler-Stevenson, and V. Quaranta. 1997. Science 277:225.
12. Chandler, S., R. Coates, A. Gearing, J. Lury, G. Wells, and E. Bone. 1995. Neurosci. Lett. 201:223.
13. Crabbe, T., J.P. O'Connell, B.J. Smith, and A.J. Docherty. 1994. Biochemistry 33:14419.
14. Fridman, R., M. Toth, D. Pena, and S. Mobashery. 1995. Cancer Res. 55:2548.
15. Knauper, V., H. Will, C. Lopez-Otin, B. Smith, S.J. Atkinson, H. Stanton, R.M. Hembry, and G. Murphy. 1996. J. Biol. Chem. 271:17124.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
MMP-2
NCBI Official Synonym Full Names
matrix metallopeptidase 2
NCBI Official Symbol
Mmp2
NCBI Official Synonym Symbols
Mmp2
NCBI Protein Information
72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; matrix metalloproteinase 2; matrix metalloproteinase-2
UniProt Protein Name
MMP-2
Protein Family
UniProt Gene Name
Mmp2
UniProt Synonym Gene Names
MMP-2
UniProt Entry Name
Q9JHC2_RAT
NCBI Description
plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD]
Research Articles on Mmp2
Similar Products
Product Notes
The Mmp2 mmp2 (Catalog #AAA670150) is an Antibody produced from Mouse (BALB/c) and is intended for research purposes only. The product is available for immediate purchase. The Mouse Anti-Human MMP-2-UNLB reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's MMP-2 can be used in a range of immunoassay formats including, but not limited to, ELISA. ELISA: < 1 ug/mL Since applications vary, you should determine the optimum working dilution for the product that is appropriate for your specific need. Researchers should empirically determine the suitability of the Mmp2 mmp2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "MMP-2, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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