Mouse anti-Human TNFRSF8, CD30 Monoclonal Antibody | anti-TNFRSF8 antibody

TNFRSF8, CD30, ID (TNFRSF8, CD30, D1S166E, Tumor necrosis factor receptor superfamily member 8, CD30L receptor, Ki-1 antigen, Lymphocyte activation antigen CD30, CD_antigen=CD30, Flags: Precursor)

Cat. Num. AAA6007378

• Gene Names: TNFRSF8; CD30; Ki-1; D1S166E
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Ascites; Ascites
• Synonyms: TNFRSF8; CD30; Monoclonal Antibody; ID (TNFRSF8; D1S166E; Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD_antigen=CD30; Flags: Precursor); Anti -TNFRSF8; anti-TNFRSF8 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 595CT15.5.1
• Specificity: Human
• Purity/Purification: Ascites; Ascites
• Form/Format: Supplied as a liquid, crude ascites with 0.09% sodium azide.

• Applicable Applications for anti-TNFRSF8 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in Western Blot, ELISA.; Dilution: ELISA: 1:1,000; Western Blot: 1:100~1000
• Immunogen: TNFRSF8/CD30 Mab is generated from mouses immunized with a KLH conjugated synthetic peptide selected from human TNFRSF8/CD30.
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Western Blot (WB)

(TNFRSF8/CD30 Antibody (Center)(Ascites) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the TNFRSF8/CD30 antibody detected the TNFRSF8/CD30 protein (arrow).)

Related Product Information for anti-TNFRSF8 antibody

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Product Categories/Family for anti-TNFRSF8 antibody

Antibodies; Abs to CD Markers

NCBI and Uniprot Product Information

• NCBI GI #: 68348711
• NCBI GeneID: 943
• NCBI Accession #: NP_001234.2
• NCBI GenBank Nucleotide #: NM_001243.3
• UniProt Accession #: P28908; Q6P4D9; B1AN79
• Molecular Weight: 63,747 Da
• NCBI Official Full Name: tumor necrosis factor receptor superfamily member 8 isoform 1
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 8
• NCBI Official Symbol: TNFRSF8
• NCBI Official Synonym Symbols: CD30; Ki-1; D1S166E
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 8; Ki-1 antigen; CD30L receptor; cytokine receptor CD30; lymphocyte activation antigen CD30
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 8
• Protein Family: Tumor necrosis factor receptor superfamily
• UniProt Gene Name: TNFRSF8
• UniProt Synonym Gene Names: CD30; D1S166E
• UniProt Entry Name: TNR8_HUMAN

NCBI Description

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Description

TNFRSF8: Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B. 2 isoforms of the human protein are produced by alternative initiation.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: cytoplasm; integral to membrane; plasma membrane

Molecular Function: transmembrane receptor activity

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; negative regulation of cell proliferation; positive regulation of apoptosis; positive regulation of TRAIL biosynthetic process; signal transduction