Testing Data
(0.5g of Human Anti-TNFalpha Antibody, (infliximab biosimilar, research grade) and infliximab (therapeutic reference product) were denatured and analyzed under reducing (R) and non-reducing (NR) conditions. Bands were visualized using Coomassie staining. Full IgG (H2L2), heavy (H) and light chains (L) are indicated.)
Human anti-Human TNF ALPHA Monoclonal Antibody | anti-TNF Alpha antibody
HUMAN ANTI TNF ALPHA (INFLIXIMAB BIOSIMILAR)
Reactivity
Human
Applications
ELISA
Purity
>98% by SDS PAGE
Synonyms
TNF ALPHA; Monoclonal Antibody; HUMAN ANTI TNF ALPHA (INFLIXIMAB BIOSIMILAR); TNF Alpha antibody|cA2; anti-TNF Alpha antibody
Host
Human
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
cA2
Specificity
TNF ALPHA
Purity/Purification
>98% by SDS PAGE
Form/Format
Human IgG1 (kappa) antibody, liquid. Phosphate buffered saline
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Purified recombinant IgG prepared by affinity chromatography on Protein A from a mammalian cell line
Concentration
IgG concentration 1.0mg/ml (varies by lot)
Applicable Applications for anti-TNF Alpha antibody
ELISA (EIA)
Application Notes
Flow Cytometry: Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls.
Immunogen
Human TNFalpha
Preservative Stabilizers
0.02% Proclin 300
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Testing Data
(0.5g of Human Anti-TNFalpha Antibody, (infliximab biosimilar, research grade) and infliximab (therapeutic reference product) were denatured and analyzed under reducing (R) and non-reducing (NR) conditions. Bands were visualized using Coomassie staining. Full IgG (H2L2), heavy (H) and light chains (L) are indicated.)
Testing Data
(0.5g of Human Anti-TNFalpha Antibody, (infliximab biosimilar, research grade) and infliximab (therapeutic reference product) were denatured and analyzed under reducing (R) and non-reducing (NR) conditions. Bands were visualized using Coomassie staining. Full IgG (H2L2), heavy (H) and light chains (L) are indicated.)
Related Product Information for anti-TNF Alpha antibody
Human Anti-TNF alpha Antibody is a research grade biosimilar of the monoclonal antibody drug infliximab. It is a recombinant human IgG1 kappa antibody with variable regions from the therapeutic infliximab antibody clone cA2.
This antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-infliximab antibodies, for example HCA214 and HCA216. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-infliximab antibody in IgG1 format as a reference standard, for example HCA213 or HCA233.
Infliximab, also known as Remicade, is a chimeric IgG1 kappa monoclonal antibody approved for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis andulcerative colitis. This therapeutic antibody is directed against TNF alpha and acts by blocking the binding of TNF alpha to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.
Anti-TNF Alpha Antibody is a non-therapeutic biosimilar of the monoclonal antibody drug infliximab (Remicade) for research use. It can be used in bioanalytical PK and ADA assays and for studying biological pathways affected by the drug.
This antibody is for research use only. It is suitable as a reference standard in a pharmacokinetic (PK) bridging ELISA with anti-infliximab antibodies, for example HCA214 and HCA216. It can also be used as capture and detection reagent in an anti-drug antibody (ADA) bridging ELISA, with an anti-infliximab antibody in IgG1 format as a reference standard, for example HCA213 or HCA233.
Infliximab, also known as Remicade, is a chimeric IgG1 kappa monoclonal antibody approved for the treatment of psoriasis, Crohn's disease, ankylosing spondylitis, psoriatic arthritis, rheumatoid arthritis andulcerative colitis. This therapeutic antibody is directed against TNF alpha and acts by blocking the binding of TNF alpha to its receptors, resulting in a down-regulation of the inflammatory response associated with autoimmune diseases.
Anti-TNF Alpha Antibody is a non-therapeutic biosimilar of the monoclonal antibody drug infliximab (Remicade) for research use. It can be used in bioanalytical PK and ADA assays and for studying biological pathways affected by the drug.
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Product Notes
The TNF Alpha (Catalog #AAA226034) is an Antibody produced from Human and is intended for research purposes only. The product is available for immediate purchase. The HUMAN ANTI TNF ALPHA (INFLIXIMAB BIOSIMILAR) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TNF ALPHA can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA). Flow Cytometry: Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using appropriate negative/positive controls. Researchers should empirically determine the suitability of the TNF Alpha for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNF ALPHA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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