FCGRT & B2M Heterodimer Active Protein | FCGRT&B2M active protein

FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His Tag)

Cat. Num. AAA8123612

• Gene Names: Fcgrt; FcRn
• Purity: >95% as determined by SDS-PAGE
• Synonyms: FCGRT & B2M Heterodimer; FCGRT & B2M Heterodimer Protein; Mouse; Recombinant (His Tag); Mouse FCGRT & B2M Heterodimer Protein; FcRn Protein; Fc fragment of IgG; receptor; transporter; alpha; FCGRT&B2M active protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Ser297&Met1-Met119

• Species: Mouse
• Activity: 1. Measured by its ability to bind human IgG1 in functional ELISA.; 2. Labeled biotin to FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His Tag) by a certain molar ratio; Using the Octet RED System. The affinity constant (Kd) of FCGRT & B2M Heterodimer Protein, Mouse, Recombinant (His Tag), Biotinylated bound to IgG1 Antibody was 1.6nM.
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Ala 24 & Ile 21
• Tag: C-His
• Protein Construction: A DNA sequence encoding the extracellular domain (Met 1-Ser 297) of mouse FCGRT (Q61559) was fused with a polyhistidine tag at the C-terminus, constructed the plasmid 1; A DNA sequence encoding the mouse B2M (P01887,105Ala/Asp)(Met 1-Met 119) constructed the plasmid 2. The two plasmids were co-expressed and the FCGRT/B2M heterodimer was purified
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Product Categories/Family for FCGRT&B2M active protein

Fc Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 170172528
• NCBI GeneID: 14132
• NCBI Accession #: NP_034319.2
• NCBI GenBank Nucleotide #: NM_010189.3
• UniProt Accession #: Q61559; P01887
• Molecular Weight: 40,093 Da
• NCBI Official Full Name: IgG receptor FcRn large subunit p51
• NCBI Official Synonym Full Names: Fc receptor, IgG, alpha chain transporter
• NCBI Official Symbol: Fcgrt
• NCBI Official Synonym Symbols: FcRn
• NCBI Protein Information: IgG receptor FcRn large subunit p51; neonatal Fc receptor; igG Fc fragment receptor transporter alpha chain
• UniProt Protein Name: IgG receptor FcRn large subunit p51
• UniProt Gene Name: Fcgrt
• UniProt Synonym Gene Names: Fcrn; FcRn
• UniProt Entry Name: FCGRN_MOUSE

Uniprot Description

FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Belongs to the immunoglobulin superfamily.

Protein type: Immunoglobulin superfamily; Receptor, misc.; Membrane protein, integral

Cellular Component: membrane; plasma membrane; integral to membrane

Molecular Function: IgG binding; beta-2-microglobulin binding; IgG receptor activity; antigen binding

Biological Process: antigen processing and presentation; immune response