Western Blot (WB)
(Western blot detection of SWAP70 in COS7,293T,C6,3T3 and Hela cell lysates and using SWAP70 mouse mAb (1:1000 diluted).Predicted band size: 70KDa.Observed band size: 70KDa.)
Mouse anti-Human, Mouse SWAP70 Monoclonal Antibody | anti-SWAP70 antibody
SWAP70 Antibody
IP ~~ 1:500
Western Blot (WB)
(Western blot detection of SWAP70 in COS7,293T,C6,3T3 and Hela cell lysates and using SWAP70 mouse mAb (1:1000 diluted).Predicted band size: 70KDa.Observed band size: 70KDa.)
Western Blot (WB)
(Western blot detection of SWAP70 in COS7,293T,C6,3T3 and Hela cell lysates and using SWAP70 mouse mAb (1:1000 diluted).Predicted band size: 70KDa.Observed band size: 70KDa.)
Immunoprecipitation (IP)
(Immunoprecipitation analysis of Hela cell lysate using SWAP70 mouse mAb.)
Immunoprecipitation (IP)
(Immunoprecipitation analysis of Hela cell lysate using SWAP70 mouse mAb.)
NCBI and Uniprot Product Information
NCBI Description
SWAP-70: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Protein type: GEFs; GEFs, Rac/Rho
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: lamellipodium; plasma membrane; nucleus; cytosol
Molecular Function: protein binding; DNA binding; calcium ion binding; ATP binding
Biological Process: actin filament bundle formation; elevation of cytosolic calcium ion concentration; regulation of protein localization; negative regulation of cell-cell adhesion mediated by integrin; isotype switching; negative regulation of actin filament depolymerization; positive regulation of actin filament bundle formation
Uniprot Description
SWAP-70: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
Protein type: GEFs, Rac/Rho; GEFs
Chromosomal Location of Human Ortholog: 11p15
Cellular Component: cytoskeleton; cytosol; lamellipodium; nucleus; plasma membrane
Molecular Function: ATP binding; calcium ion binding; DNA binding; protein binding
Biological Process: actin filament bundle formation; elevation of cytosolic calcium ion concentration; isotype switching; negative regulation of actin filament depolymerization; negative regulation of cell-cell adhesion mediated by integrin; positive regulation of actin filament bundle formation; regulation of protein localization
Research Articles on SWAP70
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Product Notes
The SWAP70 swap70 (Catalog #AAA9215441) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The SWAP70 Antibody reacts with Human, Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's SWAP70 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunoprecipitation (IP). WB ~~ 1:1000 IP ~~ 1:500. Researchers should empirically determine the suitability of the SWAP70 swap70 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SWAP70, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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