Western Blot (WB)
(Sample Data: Western blot of rat brain lysate showing specific immunolabeling of the ~ 15kDa SNCA protein.)
Mouse SNCA Monoclonal Antibody | anti-SNCA antibody
Anti-SNCA
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunofluorescence
Synonyms
SNCA; Monoclonal Antibody; Anti-SNCA; anti-SNCA antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
Mouse, IgG1
Clone Number
3H9
Specificity
Recognizes the SNCA protein
Form/Format
Ascites fluid + 0.01 % NaN3.
Applicable Applications for anti-SNCA antibody
Western Blot (WB), Immunofluorescence (IF)
Application Notes
WB: 1:1,000
IF 1:500
IF 1:500
Immunogen
Full length human alpha synuclein expressed in E Coli.
Preparation and Storage
Store at 4 degree C (add 0.1% NaN3) for several months, and at -20 degree C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Western Blot (WB)
(Sample Data: Western blot of rat brain lysate showing specific immunolabeling of the ~ 15kDa SNCA protein.)
Western Blot (WB)
(Sample Data: Western blot of rat brain lysate showing specific immunolabeling of the ~ 15kDa SNCA protein.)
Testing Data
(Sample Data: Mixed neuron-glial cultures stained with Anti-SNCA (red) and chicken Anti-MAP2 (green). The Anti-SNCA antibody stains vesicular structures, the perikarya and processes of the neurons in this image.)
Testing Data
(Sample Data: Mixed neuron-glial cultures stained with Anti-SNCA (red) and chicken Anti-MAP2 (green). The Anti-SNCA antibody stains vesicular structures, the perikarya and processes of the neurons in this image.)
Related Product Information for anti-SNCA antibody
Alpha-synuclein is expressed in the presynaptic terminal of the neuron where it is implicated in the formation of SNARE complexes. Aggregated alpha-synuclein is one of the major components found in the Lewy bodies, which are found in the brains of patients with Parkinson's disease (PD) and other neurodegenerative disorders (1). In fact, there is evidence to suggest that early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha synuclein genes (2). Alpha-synuclein is also found in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS).
Product Categories/Family for anti-SNCA antibody
References
1. Okochi, M. et al: Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J Biol Chem 2000 Jan 7;275(1): 390-7.
2. Chartier-Harlin, M C. et al: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004 364: 1167-1169.
2. Chartier-Harlin, M C. et al: Alpha-synuclein locus duplication as a cause of familial Parkinson's disease. Lancet 2004 364: 1167-1169.
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Product Notes
The SNCA (Catalog #AAA516218) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-SNCA reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's SNCA can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunofluorescence (IF). WB: 1:1,000 IF 1:500. Researchers should empirically determine the suitability of the SNCA for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SNCA, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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