Testing Data
(Image: Mixed neuron-glial cell cultures stained with RA22120 (green) and our monoclonal antibody against GFAP (red, MO22136). The CNP antibody stains strongly in oligodendrocytes, whereas GFAP labels the intermediate filament in astrocytes. Blue is DNA staining showing the nuclei of these and numerous other cells, most of which are neurons and which do not express either CNP or GFAP.)
CNP Antibody | anti-CNP antibody
CNP, Affinity Purified Antibody, Rabbit
Gene Names
CNP; CNP1
Reactivity
Human, Mouse, Rat
Applications
Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
Synonyms
CNP; Affinity Purified Antibody; Rabbit; anti-CNP antibody
Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified - Liquid
Sequence Length
401
Applicable Applications for anti-CNP antibody
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB)
Type Info
Rabbit IgG
Immunogen
Full length human recombinant protein. HGNC name: CNP UniProtKB - P09543 (CN37_HUMAN)
Testing Data
(Image: Mixed neuron-glial cell cultures stained with RA22120 (green) and our monoclonal antibody against GFAP (red, MO22136). The CNP antibody stains strongly in oligodendrocytes, whereas GFAP labels the intermediate filament in astrocytes. Blue is DNA staining showing the nuclei of these and numerous other cells, most of which are neurons and which do not express either CNP or GFAP.)
Testing Data
(Image: Mixed neuron-glial cell cultures stained with RA22120 (green) and our monoclonal antibody against GFAP (red, MO22136). The CNP antibody stains strongly in oligodendrocytes, whereas GFAP labels the intermediate filament in astrocytes. Blue is DNA staining showing the nuclei of these and numerous other cells, most of which are neurons and which do not express either CNP or GFAP.)
Related Product Information for anti-CNP antibody
CNP (2', 3'-Cyclic Nucleotide 3'-Phosophodiesterase) has two isoforms, CNPase1 (46kDa) and CNPase2 (48kDa), which are encoded separately by different promoters of the same gene. CNP is found in high levels in the brain and peripheral nerve, almost exclusively in oligodendrocytes and Schwann cells. CNP is the third most abundant protein found in the central nervous system myelin. It is found early in oligodendrocyte development and continues to be found in adult animals. It may play a role in RNA metabolism in the myelinating cell. CNP antibody can be used as a marker for oligodendrocyte and Schwann cells. CNP levels have been found to greatly reduced in various diseases, neurological mutant and in experimental conditions in which myelin is reduced. Additionally, reduced CNP brain levels have been reported in Down syndrome and Alzheimer's disease.
Product Categories/Family for anti-CNP antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
45,099 Da
NCBI Official Full Name
CNP protein
NCBI Official Synonym Full Names
2',3'-cyclic nucleotide 3' phosphodiesterase
NCBI Official Symbol
CNP
NCBI Official Synonym Symbols
CNP1
NCBI Protein Information
2',3'-cyclic-nucleotide 3'-phosphodiesterase
UniProt Protein Name
2',3'-cyclic-nucleotide 3'-phosphodiesterase
Protein Family
UniProt Gene Name
CNP
UniProt Synonym Gene Names
CNP; CNPase
UniProt Entry Name
CN37_HUMAN
Uniprot Description
CNP: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Exists as monomers and homodimers. Belongs to the cyclic nucleotide phosphodiesterase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: cytoplasm; extracellular space; membrane; nucleoplasm; nucleus
Biological Process: substantia nigra development; synaptic transmission
Similar Products
Product Notes
The CNP cnp (Catalog #AAA555612) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The CNP, Affinity Purified Antibody, Rabbit reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's CNP can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (IHC), Western Blot (WB). Researchers should empirically determine the suitability of the CNP cnp for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNP, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
