Testing Data
(Image: Mixed cultures of rat CNS cells stained with alpha-Internexin (red) and chicken antibody to Microtubule associated protein 2 (MAP2- green). The a-internexin is localized primarily in neuronal axons in these cultures, while the perikarya and dendrites of neurons stain strongly for MAP2.)
anti-Human, Rat alpha-Internexin [1D2] Antibody | anti-INA antibody
Mouse Monoclonal Anti-alpha-Internexin [1D2]
Gene Names
INA; NEF5; NF-66; TXBP-1
Reactivity
Human, Rat
Applications
Immunocytochemistry, Immunofluorescence, Western Blot
Synonyms
alpha-Internexin [1D2]; Mouse Monoclonal Anti-alpha-Internexin [1D2]; anti-INA antibody
Reactivity
Human, Rat
Form/Format
Supernatant - Liquid
Sequence Length
499
Applicable Applications for anti-INA antibody
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)
Type Info
Mouse IgG
Immunogen
Purified recombinant rat alpha-internexin expressed in and purified from E Coli. Specifically recognizes the C-terminal non-helical extension of a-internexin.
Testing Data
(Image: Mixed cultures of rat CNS cells stained with alpha-Internexin (red) and chicken antibody to Microtubule associated protein 2 (MAP2- green). The a-internexin is localized primarily in neuronal axons in these cultures, while the perikarya and dendrites of neurons stain strongly for MAP2.)
Testing Data
(Image: Mixed cultures of rat CNS cells stained with alpha-Internexin (red) and chicken antibody to Microtubule associated protein 2 (MAP2- green). The a-internexin is localized primarily in neuronal axons in these cultures, while the perikarya and dendrites of neurons stain strongly for MAP2.)
Related Product Information for anti-INA antibody
Alpha-Internexin is a ~66 kDa Class IV intermediate filament subunit expressed very early in neuronal development. It is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. Many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition the very early developmental expression of alpha-internexin means its presence is an early and convenient feature of neuronal progenitors cells and other cell committed to the neuronal lineage. The use of antibodies to this protein in the study of brain tumors has not been examined to date, but is likely to be of interest.
Product Categories/Family for anti-INA antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,391 Da
NCBI Official Full Name
alpha-internexin
NCBI Official Synonym Full Names
internexin neuronal intermediate filament protein alpha
NCBI Official Symbol
INA
NCBI Official Synonym Symbols
NEF5; NF-66; TXBP-1
NCBI Protein Information
alpha-internexin
UniProt Protein Name
Alpha-internexin
Protein Family
UniProt Gene Name
INA
UniProt Synonym Gene Names
NEF5; Alpha-Inx; NF-66; Neurofilament-66
UniProt Entry Name
AINX_HUMAN
Uniprot Description
INA: Class-IV neuronal intermediate filament that is able to self-assemble. It is involved in the morphogenesis of neurons. It may form an independent structural network without the involvement of other neurofilaments or it may cooperate with NF-L to form the filamentous backbone to which NF-M and NF-H attach to form the cross-bridges. Belongs to the intermediate filament family.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 10q24.33
Cellular Component: extracellular space; intermediate filament cytoskeleton; nuclear membrane; nucleoplasm
Molecular Function: structural constituent of cytoskeleton
Biological Process: substantia nigra development
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Product Notes
The INA ina (Catalog #AAA555019) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Mouse Monoclonal Anti-alpha-Internexin [1D2] reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's alpha-Internexin [1D2] can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Researchers should empirically determine the suitability of the INA ina for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "alpha-Internexin [1D2], Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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