SIRP-beta & gamma recombinant antibody
Anti-SIRP-beta & gamma [OX117]
Gene Names
SIRPG; CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma
Reactivity
Human
Applications
ELISA, Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
Protein A Affinity Purified
Synonyms
SIRP-beta & gamma; Monoclonal Recombinant Antibody; Anti-SIRP-beta & gamma [OX117]; Human Signal Regulatory Protein gamma; Human Signal Regulatory Protein beta; SIRP-beta & gamma recombinant antibody
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1, Kappa
Clone Number
OX117
Specificity
This antibody binds to human SIRP-beta and gamma.
Purity/Purification
Protein A Affinity Purified
Concentration
1 mg/ml (varies by lot)
Sequence Length
276
Applicable Applications for SIRP-beta & gamma recombinant antibody
ELISA (EIA), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes
This antibody binds to human Signal-regulatory protein gamma, an immunoglobulin-like cell surface receptor binding CD47. It mediates cell-cell adhesion and enhances T-cell activation.
Immunogen
Purified Human SIRP-gamma.
Buffer Composition
PBS only with 0.02% Proclin 300.
Labeled Substance
None
Preparation and Storage
Store at 4 degree C for up to 3 months. For longer storage, aliquot and store at -20 degree C.
Related Product Information for SIRP-beta & gamma recombinant antibody
Recombinant monoclonal antibody to SIRP-beta & gamma. Manufactured using a proprietary Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OX117.
Purified Human SIRP-gamma.
Purified Human SIRP-gamma.
Product Categories/Family for SIRP-beta & gamma recombinant antibody
References
Brooke et al. Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. Journal of Immunology 2004; 173(4):2562-2570 PMID:15294972
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
38,962 Da
NCBI Official Full Name
signal-regulatory protein gamma isoform 3
NCBI Official Synonym Full Names
signal regulatory protein gamma
NCBI Official Symbol
SIRPG
NCBI Official Synonym Symbols
CD172g; SIRPB2; SIRP-B2; bA77C3.1; SIRPgamma
NCBI Protein Information
signal-regulatory protein gamma
UniProt Protein Name
Signal-regulatory protein gamma
UniProt Gene Name
SIRPG
UniProt Synonym Gene Names
SIRPB2; SIRP-gamma; SIRP-b2; SIRP-beta-2
NCBI Description
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.
Research Articles on SIRP-beta & gamma
Similar Products
Product Notes
The SIRP-beta & gamma sirpg (Catalog #AAA488315) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-SIRP-beta & gamma [OX117] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's SIRP-beta & gamma can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunoprecipitation (IP), Flow Cytometry (FC/FACS). This antibody binds to human Signal-regulatory protein gamma, an immunoglobulin-like cell surface receptor binding CD47. It mediates cell-cell adhesion and enhances T-cell activation. Researchers should empirically determine the suitability of the SIRP-beta & gamma sirpg for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SIRP-beta & gamma, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
