Rabbit anti-Human PDE2A Monoclonal Antibody | anti-PDE2A antibody

Recombinant Anti-PDE2A Antibody, Rabbit Monoclonal

Cat. Num. AAA8106654

• Gene Names: PDE2A; PDE2A1; PED2A4; cGSPDE; CGS-PDE
• Reactivity: Human
• Applications: ELISA
• Purity: Protein A
• Synonyms: PDE2A; Monoclonal Antibody; Recombinant Anti-PDE2A Antibody; Rabbit Monoclonal; PDE2A Antibody; Rabbit MAb; phosphodiesterase 2A; cGMP-stimulated; Anti-CGS-PDE Antibody; Anti-cGSPDE Antibody; Anti-PDE2A1 Antibody; Anti-PED2A4 Antibody; anti-PDE2A antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 201
• Specificity: Human PDE2A
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-PDE2A antibody: ELISA (EIA)
• Application Notes: ELISA: 1:5000-1:10,000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Human PDE2A protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Human PDE2A (rh PDE2A).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-PDE2A antibody

cGMP-dependent 3', 5'-cyclic phosphodiesterase, also known as cyclic GMP-stimulated phosphodiesterase and PDE2A, is a peripheral membrane protein that belongs to the cyclic nucleotide phosphodiesterase family and PDE2 subfamily. Phosphodiesterases (PDEs) comprise a family of enzymes that regulate the levels of cyclic nucleotides, key second messengers that mediate a diverse array of functions. Phosphodiesterases (PDEs) modulate signaling by cyclic nucleotides in diverse processes such as cardiac contractility, platelet aggregation, lipolysis, glycogenolysis, and smooth muscle contraction. PDE2A is an evolutionarily conserved cGMP-stimulated cAMP and cGMP PDE. PDE2A contains two GAF domains. PDE2A is expressed in brain and to a lesser extent in heart, placenta, lung, skeletal muscle, kidney and pancreas. PDE2A is a cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. PDE2A is involved in the regulation of blood pressure and fluid homeostasis by the atrial natriuretic peptide (ANP), making PDE2-type enzymes important targets for drug discovery.

References

Iffland, A. et al., 2005, Biochemistry. 44 (23):8312-25 de Oliveira, S.K. et al., 2007, J Biol Chem. 282 (18):13656-63. Stephenson, D.T. et al., 2009, J Histochem Cytochem. 57 (10):933-49. Russwurm, C. et al., 2009, J Biol Chem. 284 (38):25782-90.

NCBI and Uniprot Product Information

• NCBI GI #: 219802706
• NCBI GeneID: 5138
• NCBI Accession #: NP_001137311.1
• NCBI GenBank Nucleotide #: NM_001143839.3
• UniProt Accession #: O00408; Q5J791; Q5J792; Q5J793; Q6ZMR1; B2R646; B3KRV5; E9PGI1; F6W5Z0
• Molecular Weight: 87,235 Da
• NCBI Official Full Name: cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2
• NCBI Official Synonym Full Names: phosphodiesterase 2A, cGMP-stimulated
• NCBI Official Symbol: PDE2A
• NCBI Official Synonym Symbols: PDE2A1; PED2A4; cGSPDE; CGS-PDE
• NCBI Protein Information: cGMP-dependent 3',5'-cyclic phosphodiesterase; cGMP-stimulated phosphodiesterase 1; cGMP-stimulated phosphodiesterase 4; cyclic GMP-stimulated phosphodiesterase
• UniProt Protein Name: cGMP-dependent 3',5'-cyclic phosphodiesterase
• Protein Family: cGMP-dependent 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE2A
• UniProt Synonym Gene Names: CGS-PDE; cGSPDE
• UniProt Entry Name: PDE2A_HUMAN

Uniprot Description

PDE2A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Mitochondrial; Phosphodiesterase; EC 3.1.4.17; Nucleotide Metabolism - purine

Chromosomal Location of Human Ortholog: 11q13.4

Cellular Component: presynaptic membrane; Golgi apparatus; mitochondrial matrix; axon; endoplasmic reticulum; perinuclear region of cytoplasm; dendrite; cytoplasm; plasma membrane; nucleus; cytosol

Molecular Function: protein binding; protein homodimerization activity; TPR domain binding; calcium channel activity; metal ion binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cGMP binding; cyclic-nucleotide phosphodiesterase activity; drug binding; cAMP binding

Biological Process: monocyte differentiation; metabolic process; cGMP-mediated signaling; cAMP catabolic process; negative regulation of transcription from RNA polymerase II promoter; positive regulation of vascular permeability; cAMP-mediated signaling; negative regulation of cAMP biosynthetic process; negative regulation of protein import into nucleus, translocation; negative regulation of vascular permeability; regulation of cGMP metabolic process; cGMP catabolic process; blood coagulation; protein targeting to mitochondrion; positive regulation of inflammatory response