Western Blot (WB)
PDE2A positive control
PDE2A Positive Control
Western Blot (WB)
Western Blot (WB)
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.
NCBI and Uniprot Product Information
Uniprot Description
PDE2A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nucleotide Metabolism - purine; Mitochondrial; EC 3.1.4.17; Phosphodiesterase
Chromosomal Location of Human Ortholog: 11q13.4
Cellular Component: cytoplasm; cytosol; endoplasmic reticulum; Golgi apparatus; lipid raft; mitochondrial matrix; nucleus; perinuclear region of cytoplasm; plasma membrane; presynaptic membrane
Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; calcium channel activity; cAMP binding; cGMP binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cyclic-nucleotide phosphodiesterase activity; drug binding; metal ion binding; protein binding; protein homodimerization activity; TPR domain binding
Biological Process: cAMP catabolic process; cAMP-mediated signaling; cGMP catabolic process; cGMP-mediated signaling; metabolic process; monocyte differentiation; negative regulation of cAMP biosynthetic process; negative regulation of protein import into nucleus, translocation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of vascular permeability; positive regulation of inflammatory response; positive regulation of vascular permeability; protein targeting to mitochondrion
Research Articles on PDE2A
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Product Notes
The PDE2A pde2a (Catalog #AAA543065) is a Positive Control and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PDE2A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot: 1:250-1:1,000. Researchers should empirically determine the suitability of the PDE2A pde2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PDE2A, Positive Control" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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