Rat PD1 Monoclonal Antibody | anti-PD1 antibody
PD1 antibody
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Uniprot Description
PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.
Protein type: Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: integral to membrane; plasma membrane; external side of plasma membrane
Molecular Function: signal transducer activity; protein binding
Biological Process: apoptosis; multicellular organismal development; T cell costimulation; signal transduction; humoral immune response
Disease: Systemic Lupus Erythematosus
Research Articles on PD1
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Product Notes
The PD1 pdcd1 (Catalog #AAA834076) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's PD1 can be used in a range of immunoassay formats including, but not limited to, Functional Assay. The ED50 of this protein, as measured by balb/c-3T3 cell proliferation, is 0.1-1.25 ng/ml. This corresponds to a specific activity of 1 x 10?- 8 x10? Units/mg. Researchers should empirically determine the suitability of the PD1 pdcd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PD1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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