Western Blot (WB)
(Anti-PD1 Picoband antibody, -1.jpgAll lanes: Anti PD1 at 0.5ug/mlWB: Recombinant Human PD1 Protein 0.5ngPredicted bind size: 38KDObserved bind size: 38KD)
anti-Human, Rat PD1 Polyclonal Antibody | anti-PD1 antibody
Anti-PD1 Antibody
Western Blot (WB)
(Anti-PD1 Picoband antibody, -1.jpgAll lanes: Anti PD1 at 0.5ug/mlWB: Recombinant Human PD1 Protein 0.5ngPredicted bind size: 38KDObserved bind size: 38KD)
Western Blot (WB)
(Anti-PD1 Picoband antibody, -1.jpgAll lanes: Anti PD1 at 0.5ug/mlWB: Recombinant Human PD1 Protein 0.5ngPredicted bind size: 38KDObserved bind size: 38KD)
Testing Data
(Anti-PD1 Picoband antibody, -2.jpgAll lanes: Anti PD1 at 0.5ug/mlLane 1: JURKAT Whole Cell Lysate at 40ugLane 2: Human Placenta Tissue Lysate at 50ugPredicted bind size: 32KDObserved bind size: 38KD)
Testing Data
(Anti-PD1 Picoband antibody, -2.jpgAll lanes: Anti PD1 at 0.5ug/mlLane 1: JURKAT Whole Cell Lysate at 40ugLane 2: Human Placenta Tissue Lysate at 50ugPredicted bind size: 32KDObserved bind size: 38KD)
Background: PDCD1(Programmed cell death 1), also called PD1, encodes a cell surface receptor that is a member of the B7 superfamily involved in immunomodulation. This gene is mapped to 2q37.3. PDCD1 acts as an inhibitory molecule on T cells after interacting with its ligands PDL1 and PDL2. The PDCD1 gene contains 5 exons. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. Using flow cytometric analysis, It has been found that expression of PDCD1 was upregulated on CD16-positive and CD16-negative monocytes, but not on dendritic cells, in viremic HIV-positive patients, but not in highly active antiretroviral therapy (HAART)-treated HIV-positive patients. PDCD1 upregulation in monocytes was induced by microbial Toll-like receptor ligands and inflammatory cytokines.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Uniprot Description
PDCD1: a single-pass type I membrane protein. A negative regulator of activated T cells, is upregulated in human and mouse 'exhausted' T cells during persistent viral infection. A marker of angioimmunoblastic T-cell lymphoma and germinal center associated T cells.
Protein type: Membrane protein, integral; Apoptosis
Chromosomal Location of Human Ortholog: 2q37.3
Cellular Component: external side of plasma membrane; integral to membrane; plasma membrane
Molecular Function: protein binding; signal transducer activity
Biological Process: apoptosis; humoral immune response; multicellular organismal development; negative regulation of apoptosis; negative regulation of tolerance induction; signal transduction; T cell costimulation
Disease: Systemic Lupus Erythematosus
Research Articles on PD1
Similar Products
Product Notes
The PD1 pdcd1 (Catalog #AAA177728) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-PD1 Antibody reacts with Human, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's PD1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the PD1 pdcd1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "PD1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
