Western Blot (WB)
(Western blot analysis of ORAI3 in rat spleen lysate with ORAI3 antibody at 2 ug/mL.)
Mouse ORAI3 Monoclonal Antibody | anti-ORAI3 antibody
ORAI3 Monoclonal Antibody
Gene Names
Orai3; BC061259; Tmem142c; 9930124N15
Applications
ELISA, Western Blot, Immunohistochemistry
Purity
Immunoaffinity chromotography purified IgG
Synonyms
ORAI3; Monoclonal Antibody; ORAI3 Monoclonal Antibody; ORAI3 (2H2G9); Transmembrane protein 142C; TMEM142C; Calcium release-activated calcium channel protein 3; anti-ORAI3 antibody
Host
Mouse
Clonality
Monoclonal
Clone Number
2H2G9
Purity/Purification
Immunoaffinity chromotography purified IgG
Form/Format
Supplied in PBS containing 0.02% sodium azide.
Sequence Length
290
Applicable Applications for anti-ORAI3 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Immunogen Type
Peptide
Immunogen Description
A 19 amino acid peptide from near the carboxy terminus of human ORAI3.
Target Name
ORAI3
Preparation and Storage
Can be stored at -20 degree C, stable for one year.
Western Blot (WB)
(Western blot analysis of ORAI3 in rat spleen lysate with ORAI3 antibody at 2 ug/mL.)
Western Blot (WB)
(Western blot analysis of ORAI3 in rat spleen lysate with ORAI3 antibody at 2 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ORAI3 in rat spleen tissue with ORAI3 antibody at 2.5 ug/mL.)
Immunohistochemistry (IHC)
(Immunohistochemistry of ORAI3 in rat spleen tissue with ORAI3 antibody at 2.5 ug/mL.)
Related Product Information for anti-ORAI3 antibody
Antigen stimulation of immune cells triggers Ca++ entry t hrough Ca++ release-activated Ca++ (CRAC) channels. ORAI3 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. All three homologs have been shown to function as Ca++ plasma membrane channels gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor. However, ORAI3 channels failed to produce detectable Ca++ selective currents in cells co-transfected with ORAI3 and STIM1, indicating that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. Na+ currents through ORAI1, 2 and 3 channels were equally inhibited by extracellular Ca++, indicating that each have similar affinities for Ca++ within the selectivity filter. This antibody is predicted to have no cross-reactivity to ORAI1 or ORAI2. Larger molecular weight bands are sometimes seen in SDS-PAGE; these may represent post-translationally modified ORAI 3.
Product Categories/Family for anti-ORAI3 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
31,358 Da
NCBI Official Full Name
Orai3
NCBI Official Synonym Full Names
ORAI calcium release-activated calcium modulator 3
NCBI Official Symbol
Orai3
NCBI Official Synonym Symbols
BC061259; Tmem142c; 9930124N15
NCBI Protein Information
protein orai-3
UniProt Protein Name
Protein orai-3
Protein Family
UniProt Gene Name
Orai3
UniProt Synonym Gene Names
Tmem142c
UniProt Entry Name
ORAI3_MOUSE
Uniprot Description
TMEM142C: Key regulator or component of store-operated Ca(2+) channel and transcription factor NFAT nuclear import. Belongs to the Orai family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Cellular Component: membrane; integral to membrane
Similar Products
Product Notes
The ORAI3 orai3 (Catalog #AAA9400189) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's ORAI3 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the ORAI3 orai3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "ORAI3, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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