Rabbit anti-Mouse Neuroserpin Monoclonal Antibody | anti-SerpinI1 antibody

Recombinant Anti-Neuroserpin Antibody, Rabbit Monoclonal

Cat. Num. AAA8112162

• Gene Names: Serpini1; Ns; PI12; PI-12; Spi17; AI837402
• Reactivity: Mouse
• Applications: Immunohistochemistry
• Purity: Protein A
• Synonyms: Neuroserpin; Monoclonal Antibody; Recombinant Anti-Neuroserpin Antibody; Rabbit Monoclonal; Neuroserpin/SerpinI1 Antibody; Rabbit MAb; serpin peptidase inhibitor; clade I (neuroserpin); member 1; Anti-AI837402 Antibody; Anti-Ns Antibody; Anti-PI-12 Antibody; Anti-PI12 Antibody; Anti-Serpin I1 Antibody; Anti-Spi17 Antibody; anti-SerpinI1 antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Monoclonal
• Isotype: Rabbit IgG
• Clone Number: 002
• Specificity: Mouse Neuroserpin/SerpinI1.; No cross-reactivity in ELISA with Human SERPINA1, Human SERPINA3, Human SERPINA5, Human SERPINA12, Human SERPINB6, Human SERPINB9, Human SERPINC1, Human SERPIND1, Human SERPINF2, Human SERPING1, Human SERPINI2; Has cross-reactivity in ELISA with Human SERPINI1
• Purity/Purification: Protein A
• Form/Format: Liquid; 0.2um filtered solution in PBS

• Applicable Applications for anti-SerpinI1 antibody: Immunohistochemistry-Paraffin (IHC-P)
• Application Notes: IHC-P: 1:500-1:2000
• Antibody Type: Recombinant Antibody
• Immunogen: Recombinant Mouse Neuroserpin/SerpinI1 protein
• Conjugation: Unconjugated
• Preparation: This antibody was obtained from a rabbit immunized with purified, recombinant Mouse Neuroserpin/SerpinI1 (rM Neuroserpin/SerpinI1).
• Preparation and Storage: This antibody can be stored at 2-8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Avoid repeated freeze-thaw cycles.

Immunohistochemistry (IHC)

(Immunochemical staining of mouse serpinI1 in mouse brain (from 2 donors) with rabbit monoclonal antibody (1:1000, formalin-fixed paraffin embedded sections).)

Related Product Information for anti-SerpinI1 antibody

Neuroserpin, also known as Protease inhibitor 12 and SERPINI1, is a secreted protein that belongs to the serpin family. Neuroserpin is a serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons. Neuroserpin is predominantly expressed in the brain, and is expressed in the late stages of neurogenesis during the process of synapse formation. Overexpression of neuroserpin in an anterior pituitary corticotroph cell line results in the extension of neurite-like processes, suggesting that neuroserpin may play a role in cell communication, cell adhesion, and/or cell migration. Neuroserpin may be involved in the formation or reorganization of synaptic connections, as well as synaptic plasticity in the adult nervous system. Neuroserpin may also protect neurons from cell damage by tissue-type plasminogen activator. Defects of neuroserpin are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B).

References

Schrimpf SP. et al., 1997, Genomics. 40 (1): 55-62. Hill RM. et al., 2002, Ann N Y Acad Sci. 971: 406-15. Yepes M. et al., 2004, Thromb. Haemost. 91 (3): 457-64. Galliciotti G. et al., 2006, Front Biosci. 11: 33-45.

NCBI and Uniprot Product Information

• NCBI GI #: 6678091
• NCBI GeneID: 20713
• NCBI Accession #: NP_033276.1
• NCBI GenBank Nucleotide #: NM_009250.2
• UniProt Accession #: O35684; Q543F7; Q922U6
• Molecular Weight: 160,000
• NCBI Official Full Name: neuroserpin
• NCBI Official Synonym Full Names: serine (or cysteine) peptidase inhibitor, clade I, member 1
• NCBI Official Symbol: Serpini1
• NCBI Official Synonym Symbols: Ns; PI12; PI-12; Spi17; AI837402
• NCBI Protein Information: neuroserpin; serpin I1; protease inhibitor 17; peptidase inhibitor 12; serine protease inhibitor 17
• UniProt Protein Name: Neuroserpin
• Protein Family: Neuroserpin
• UniProt Gene Name: Serpini1
• UniProt Synonym Gene Names: Pi12; Spi17; PI-12
• UniProt Entry Name: NEUS_MOUSE

Uniprot Description

SERPINI1: Serine protease inhibitor that inhibits plasminogen activators and plasmin but not thrombin. May be involved in the formation or reorganization of synaptic connections as well as for synaptic plasticity in the adult nervous system. May protect neurons from cell damage by tissue-type plasminogen activator. Defects in SERPINI1 are the cause of familial encephalopathy with neuroserpin inclusion bodies (FEN1B). FEN1B is characterized clinically as an autosomal dominantly inherited dementia, histologically by unique neuronal inclusion bodies and biochemically by polymers of neuroserpin. Belongs to the serpin family.

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; protease inhibitor activity

Biological Process: regulation of cell adhesion; negative regulation of peptidase activity