Mouse anti-Human Ki-67 Monoclonal Antibody | anti-Ki-67 antibody

Anti- Ki-67 Antibody (IHC067)

Cat. Num. AAA847376

• Gene Names: MKI67; KIA
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Protein A/G purification
• Synonyms: Ki-67; Monoclonal Antibody; Anti- Ki-67 Antibody (IHC067); Proliferation marker protein Ki-67; Ki67; KI-67; MKI67; anti-Ki-67 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Clone Number: IHC067
• Specificity: Monoclonal Antibody to detect Ki-67 in human samples
• Purity/Purification: Protein A/G purification
• Form/Format: Colorless liquid. Tris Buffer, pH7.3-7.7, with 1% BSA and <0.1% Sodium Azide

• Applicable Applications for anti-Ki-67 antibody: Immunohistochemistry (IHC)
• Application Notes: IHC: 1:100-1:200
• Immunogen: Ki-67
• Positive Control: IHC: Cervical cancer tissue
• Preparation and Storage: Store at 4 degree C; The antibody solution should be gently mixed before use; Shelf life: ~12 months

Immunohistochemistry (IHC)

Related Product Information for anti-Ki-67 antibody

Ki-67 is a nuclear, non-histone protein that is expressed only during active phases of the cell cycle (G1, S, G2 and M), but not in the resting phases (G0 and G1 early phase). Although the antigen has also been associated with ribosomal RNA transcription, it is strongly linked to cell proliferation and has thus been indicated as an effective marker in grading the proliferation rate of tumors, including those of the brain, breast, cervix, and prostate.

Product Categories/Family for anti-Ki-67 antibody

Immunology; Antibodies & Supporting Tools; Marker Antibodies; Cell Cycle

NCBI and Uniprot Product Information

• NCBI GI #: 225543215
• NCBI GeneID: 4288
• NCBI Accession #: NP_001139438.1
• NCBI GenBank Nucleotide #: NM_001145966.1
• UniProt Accession #: P46013; Q5VWH2
• Molecular Weight: 358,694 Da
• NCBI Official Full Name: antigen KI-67 isoform 2
• NCBI Official Synonym Full Names: antigen identified by monoclonal antibody Ki-67
• NCBI Official Symbol: MKI67
• NCBI Official Synonym Symbols: KIA
• NCBI Protein Information: antigen KI-67; proliferation-related Ki-67 antigen
• UniProt Protein Name: Antigen KI-67
• UniProt Gene Name: MKI67
• UniProt Entry Name: KI67_HUMAN

NCBI Description

This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

Uniprot Description

KI-67: a protein that may be a marker of proliferating cells, involved in chromatin compaction. Its expression is altered in many tumor types including osteosarcomas, histiocytomas, prostate, breast and esophageal cancers. Mutated in colon, cervical and lung cancers.

Protein type: Nucleolus; Cell cycle regulation

Chromosomal Location of Human Ortholog: 10q26.2

Cellular Component: membrane; cytoplasm; nucleolus; condensed chromosome; nucleus; chromosome, pericentric region

Molecular Function: protein C-terminus binding; protein binding; ATP binding

Biological Process: cell proliferation; meiosis