Mouse Histone acetyltransferase KAT2A Monoclonal Antibody | anti-KAT2A antibody

Mouse Anti Human Histone acetyltransferase KAT2A

Cat. Num. AAA140349

• Gene Names: KAT2A; GCN5; hGCN5; GCN5L2; PCAF-b
• Applications: ELISA, Western Blot, Immunofluorescence
• Purity: KAT2A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Synonyms: Histone acetyltransferase KAT2A; Monoclonal Antibody; Mouse Anti Human Histone acetyltransferase KAT2A; KAT2A Antibody; Mouse Anti Human; General control of amino acid synthesis protein 5-like 2; Histone acetyltransferase GCN5; HsGCN5; Lysine acetyltransferase 2A; STAF97; KAT2A; GCN5; GCN5L2; HGCN5; PCAF-b; MGC102791; anti-KAT2A antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2a heavy chain and kappa light chain
• Clone Number: PAT3G13AT
• Purity/Purification: KAT2A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
• Form/Format: 1mg/ml containing PBS, pH-7.4, & 0.1% Sodium Azide.
• Sequence Length: 837

• Applicable Applications for anti-KAT2A antibody: ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
• Application Notes: KAT2A antibody has been tested by ELISA, Western blot and Immunofluorescence analysis to assure specificity and reactivity. Since application varies, however, each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis and Immunofluorescence is 1:250 ~ 500.Recommended starting dilution is 1:250.
• Immunogen: Anti-human KAT2A mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KAT2A amino acids 411-837 purified from E Coli.
• Preparation and Storage: For periods up to 1 month store at 4 degree C, for longer periods of time, store at -20 degree C. Prevent freeze thaw cycles.; 12 months at -20 degree C. 1 month at 4 degree C.

Related Product Information for anti-KAT2A antibody

Introduction: KAT2A (GCN5L2 or GCN5) is a histone acetyltransferase (HAT), which functions mainly as a transcriptional activator. GCN5L2 may be one of the enzymes involved in acetylation in vivo. GCN5 is expressed primarily in the embryo and newborn and is crucial for normal embryonic development. Hence, KAT2A appears to be significant for differentiation of embryonic-derived preadipocytes. GCN5 also functions as a repressor of NF-kappa-B by promoting ubiquitination of the NF-kappa-B subunit RELA in a HAT-independent manner. Loss of GCN5L2 leads to a high occurrence of apoptosis in the KAT2A mutants, which begins before the onset of morphological abnormality.

Product Categories/Family for anti-KAT2A antibody

Monoclonal Antibodies; Anti-Human Enzymes; Monoclonal Antibodies; Anti Human Enzyme

NCBI and Uniprot Product Information

• NCBI GI #: 153791535
• NCBI GeneID: 2648
• NCBI Accession #: NP_066564.2
• NCBI GenBank Nucleotide #: NM_021078.2
• Molecular Weight: 48,921 Da
• NCBI Official Full Name: histone acetyltransferase KAT2A
• NCBI Official Synonym Full Names: K(lysine) acetyltransferase 2A
• NCBI Official Symbol: KAT2A
• NCBI Official Synonym Symbols: GCN5; hGCN5; GCN5L2; PCAF-b
• NCBI Protein Information: histone acetyltransferase KAT2A; GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 2; General control of amino acid synthesis, yeast, homolog-like 2; STAF97; general control of amino acid synthesis protein 5-like 2; histone acetyltransferase GCN5; hsGCN5; lysine acetyltransferase 2A
• UniProt Protein Name: Histone acetyltransferase KAT2A
• Protein Family: Histone acetyltransferase
• UniProt Gene Name: KAT2A
• UniProt Synonym Gene Names: GCN5; GCN5L2; HGCN5; HsGCN5
• UniProt Entry Name: KAT2A_HUMAN

NCBI Description

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

Uniprot Description

GCN5: an ubiquitous histone acetyltransferase that promotes transcriptional activation. Acetylation of histones gives a specific tag for epigenetic transcription activation. Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles. Interacts with P300, CBP, ADA2, and is a component of the TFTC-HAT complex. Two splice variant isoforms have been described.

Protein type: EC 2.3.1.48; Acetyltransferase

Chromosomal Location of Human Ortholog: 17q21

Cellular Component: nucleoplasm; extracellular space

Molecular Function: protein binding; histone acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; chromatin binding; H3 histone acetyltransferase activity

Biological Process: transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; somitogenesis; viral reproduction; in utero embryonic development; multicellular organism growth; regulation of protein stability; metencephalon development; histone deubiquitination; regulation of transcription from RNA polymerase II promoter; chromatin remodeling; cell proliferation; telencephalon development; midbrain development; neural tube closure