Mouse anti-Human, Mouse GYS1 Monoclonal Antibody | anti-GYS1 antibody
GYS1 Antibody
WB: 1:500-1:2000
FC/FACS: 1:200-1:400
IF/ICC: 1:100-1:500
Function: Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1, 4-glucan.
Subunit Structure: Interacts with GYG1.
Post-translational Modifications: Phosphorylation at Ser-8 by AMPK inactivates the enzyme activity. Primed phosphorylation at Ser-657 (site 5) by CSNK2A1 and CSNK2A2 is required for inhibitory phosphorylation at Ser-641 (site 3a), Ser-645 (site 3b), Ser-649 (site 3c) and Ser-653 (site 4) by GSK3A an GSK3B (By similarity). Phosphorylated at Ser-641 by DYRK2, leading to inactivation (By similarity). Phosphorylated at Ser-641 by PASK, leading to inactivation; phosphorylation by PASK is inhibited by glycogen. Dephosphorylation at Ser-641 and Ser-645 by PP1 activates the enzyme.
Similarity: Belongs to the glycosyltransferase 3 family.
NCBI and Uniprot Product Information
Predicted: 84 kDa
NCBI Description
The protein encoded by this gene catalyzes the addition of glucose monomers to the growing glycogen molecule through the formation of alpha-1,4-glycoside linkages. Mutations in this gene are associated with muscle glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Uniprot Description
Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan.