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Western Blot (WB) ()

Mouse GSK3 beta Monoclonal Antibody | anti-GSK3 beta antibody

GSK3 beta antibody

Gene Names
Gsk3b; GSK3; GSK-3; C86142; GSK-3beta; 7330414F15Rik; 8430431H08Rik
Applications
ELISA, Western Blot
Purity
GSK3 beta antibody was purified by ammonium sulfate precipitation
Synonyms
GSK3 beta; Monoclonal Antibody; GSK3 beta antibody; Monoclonal GSK3 beta; Anti-GSK3 beta; GSK3B; glycogen synthase kinase 3 beta; BOS_771; C86142; FA; factor A; fb68h05; fk80d11; glycogen synthase kinase-3 beta; glycogen synthase kinase 3 beta variant 1; glycogen synthase kinase 3 beta variant 2; glycogen synthase kinase 3 beta variant 3; glycogen synthase kinase 3 beta variant 4; gsk3; GSK-3; GSK-3[b]; gsk3-beta; GSK3beta; GSK-3beta; GSK-3 beta; GSK3beta isoform; hypothetical protein; intracellular kinase; serine/threonine-protein kinase GSK3B; xgsk-3; anti-GSK3 beta antibody
Ordering
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1 kappa
Clone Number
AF12E8
Purity/Purification
GSK3 beta antibody was purified by ammonium sulfate precipitation
Form/Format
Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol
Sequence Length
420
Applicable Applications for anti-GSK3 beta antibody
ELISA (EIA), Western Blot (WB)
Application Notes
WB: 1:2000
Biological Significance
GSK3 beta is a cytoplasmic serine/threonine protein kinase, which was initially identified as the kinase that phosphorylates glycogen synthase to inhibit glycogen synthesis. GSK3 beta is a ubiquitously expressed kinase that regulates a wide variety of cellular functions including metabolism, gene expression and cytoskeletal integrity.
Cross-Reactivity
Human, Mouse, Rat
Immunogen
GSK3 beta antibody was raised in Mouse using a recombinant human protein purified from E Coli (His-GSK3B) as the immunogen
Preparation and Storage
Aliquot and store for 1 year at -20 degree C, avoid freeze/thaw cycles

Western Blot (WB)

()

Western Blot (WB) ()
Related Product Information for anti-GSK3 beta antibody
Mouse monoclonal GSK3 beta antibody
Product Categories/Family for anti-GSK3 beta antibody

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
46,710 Da
NCBI Official Full Name
glycogen synthase kinase-3 beta
NCBI Official Synonym Full Names
glycogen synthase kinase 3 beta
NCBI Official Symbol
Gsk3b
NCBI Official Synonym Symbols
GSK3; GSK-3; C86142; GSK-3beta; 7330414F15Rik; 8430431H08Rik
NCBI Protein Information
glycogen synthase kinase-3 beta
UniProt Protein Name
Glycogen synthase kinase-3 beta
UniProt Gene Name
Gsk3b
UniProt Synonym Gene Names
GSK-3 beta
UniProt Entry Name
GSK3B_MOUSE

Uniprot Description

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: EC 2.7.11.26; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Protein kinase, CMGC; Kinase, protein; CMGC group; GSK family; GSK subfamily

Cellular Component: centrosome; protein complex; dendritic spine; ribonucleoprotein complex; beta-catenin destruction complex; cytosol; lipid raft; nucleoplasm; growth cone; cell soma; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; dendritic shaft; nucleus

Molecular Function: p53 binding; nucleotide binding; beta-catenin binding; transcription factor binding; protein kinase binding; protein kinase activity; transferase activity; integrin binding; protein serine/threonine kinase activity; NF-kappaB binding; ionotropic glutamate receptor binding; protein binding; ubiquitin protein ligase binding; transferase activity, transferring phosphorus-containing groups; tau-protein kinase activity; kinase activity; tau protein binding; ATP binding

Biological Process: fat cell differentiation; circadian rhythm; glycogen metabolic process; negative regulation of MAP kinase activity; re-entry into mitotic cell cycle; genetic imprinting; positive regulation of protein binding; positive regulation of apoptosis; positive regulation of axon extension; protein amino acid autophosphorylation; multicellular organismal development; establishment and/or maintenance of cell polarity; rhythmic process; Wnt receptor signaling pathway through beta-catenin; protein amino acid phosphorylation; positive regulation of protein export from nucleus; protein export from nucleus; cell differentiation; negative regulation of protein binding; positive regulation of cell-matrix adhesion; myoblast fusion; ER overload response; nervous system development; regulation of microtubule-based process; cell migration; Wnt receptor signaling pathway; hippocampus development; myotube differentiation; negative regulation of dendrite morphogenesis; cytoskeleton organization and biogenesis; negative regulation of NFAT protein import into nucleus; positive regulation of peptidyl-serine phosphorylation; negative regulation of signal transduction; cell proliferation; negative regulation of neuron maturation; organ morphogenesis; peptidyl-serine phosphorylation; positive regulation of protein complex assembly; axonogenesis; establishment of cell polarity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; carbohydrate metabolic process; epithelial to mesenchymal transition; positive regulation of transcription from RNA polymerase II promoter; negative regulation of protein complex assembly; phosphorylation; negative regulation of apoptosis; regulation of neuronal synaptic plasticity

Research Articles on GSK3 beta

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Product Notes

The GSK3 beta gsk3b (Catalog #AAA838553) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GSK3 beta can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB). WB: 1:2000. Researchers should empirically determine the suitability of the GSK3 beta gsk3b for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GSK3 beta, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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