Rabbit anti-Human FLRT1  Monoclonal Antibody | anti-FLRT1  antibody

Rabbit anti Human FLRT1  Monoclonal Antibody

Cat. Num. AAA2544235

• Gene Names: FLRT1; SPG68
• Reactivity: Human
• Applications: ELISA
• Synonyms: FLRT1 ; Monoclonal Antibody; Rabbit anti Human FLRT1 Monoclonal Antibody; anti-FLRT1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Sequence Length: 674

• Applicable Applications for anti-FLRT1 antibody: ELISA (EIA)
• Application Notes: ELISA: 0.1-0.2 mug/mL. This antibody can be used at 0.1-0.2 mug/mL with the appropriate secondary reagents to detect Human FLRT1. The detection limit for Human FLRT1 is approximately 0.039 ng/well.
• Immunogen: Recombinant Human FLRT1 protein
• Buffer: 0.2 mum filtered solution in PBS with 5% trehalose
• Preparation and Storage: This antibody can be stored at 2 degree C- 8 degree C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20 degree C to -80 degree C. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

Related Product Information for anti-FLRT1  antibody

The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. FLRT1 is expressed in kidney and brain, which is a target for tyrosine phosphorylation mediated by FGFR1 and implicate a non-receptor Src family kinase (SFK). All FLRTs can interact with FGFR1 and FLRTs can be induced by the activation of FGF signalling by FGF-2. The phosphorylation state of FLRT1, which is itself FGFR1 dependent, may play a critical role in the potentiation of FGFR1 signalling and may also depend on a SFK-dependent phosphorylation mechanism acting via the FGFR. This is consistent with an 'in vivo' role for FLRT1 regulation of FGF signalling via SFKs. Furthermore, the phosphorylation-dependent futile cycle mechanism controlling FGFR1 signalling is concurrently crucial for regulation of FLRT1-mediated neurite outgrowth. FLRT1, FLRT2 and FLRT3 are members of the fibronectin leucine rich transmembrane protein (FLRT) family. They may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. FLRT3 shares 55% amino acid sequence identity with FLRT1.

NCBI and Uniprot Product Information

• NCBI GI #: 37181736
• NCBI GeneID: 23769
• Molecular Weight: 71,358 Da
• NCBI Official Full Name: FLRT1
• NCBI Official Synonym Full Names: fibronectin leucine rich transmembrane protein 1
• NCBI Official Symbol: FLRT1
• NCBI Official Synonym Symbols: SPG68
• NCBI Protein Information: leucine-rich repeat transmembrane protein FLRT1
• UniProt Protein Name: Leucine-rich repeat transmembrane protein FLRT1
• UniProt Gene Name: FLRT1
• UniProt Entry Name: FLRT1_HUMAN

NCBI Description

This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. The family members may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. The encoded protein shares sequence similarity with two other family members, FLRT2 and FLRT3. This gene is expressed in kidney and brain. [provided by RefSeq, Jul 2008]

Uniprot Description

FLRT1: May have a function in cell adhesion and/or receptor signaling.

Protein type: Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: cytoplasm; cytoplasmic vesicle; focal adhesion; integral to plasma membrane; intercellular junction; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; dendrite development; fibroblast growth factor receptor signaling pathway; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity