Mouse anti-Human FALZ Monoclonal Antibody | anti-FALZ antibody

Mouse monoclonal antibody Anti-Human FALZ

Cat. Num. AAA120266

• Gene Names: BPTF; FAC1; FALZ; NURF301
• Reactivity: Human
• Applications: Dot Blot
• Synonyms: FALZ; Monoclonal Antibody; Mouse monoclonal antibody Anti-Human FALZ; Homo sapiens bromodomain PHD finger transcription factor (BPTF); transcript variant 1; BPTF;FAC1; NURF301; anti-FALZ antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: 2343C3a
• Concentration: 100 ug/ml (1.0 ml) (varies by lot)
• Sequence Length: 10914

• Applicable Applications for anti-FALZ antibody: Dot Blot (DB)
• Preparation: This antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
• Sterility: Filtered through a 0.22 um membrane.

Quality Control

(Western blot analysis of immunized recombinant protein, using anti-FALZ monoclonal antibody. )

Quality Control #2

(Arrow indicates the region of immunized recombinant protein carrying 50-200 amino acids.)

Related Product Information for anti-FALZ antibody

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [NCBI Entrez Gene Summary]

NCBI and Uniprot Product Information

• NCBI GI #: 119395731
• NCBI GeneID: 2186
• NCBI Accession #: NP_872579.2
• NCBI GenBank Nucleotide #: NM_182641
• Molecular Weight: 322,217 Da
• NCBI Official Full Name: Homo sapiens bromodomain PHD finger transcription factor (BPTF), transcript variant 1, mRNA
• NCBI Official Synonym Full Names: bromodomain PHD finger transcription factor
• NCBI Official Symbol: BPTF
• NCBI Official Synonym Symbols: FAC1; FALZ; NURF301
• NCBI Protein Information: nucleosome-remodeling factor subunit BPTF; bromodomain and PHD domain transcription factor; bromodomain and PHD finger-containing transcription factor; fetal Alz-50 clone 1 protein; fetal Alz-50 reactive clone 1; fetal Alzheimer antigen; nucleosome remodeling factor, large subunit
• UniProt Protein Name: Nucleosome-remodeling factor subunit BPTF
• UniProt Gene Name: BPTF
• UniProt Entry Name: BPTF_HUMAN

NCBI Description

This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]

Uniprot Description

FALZ: Histone-binding component of NURF (nucleosome-remodeling factor), a complex which catalyzes ATP-dependent nucleosome sliding and facilitates transcription of chromatin. Specifically recognizes H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of virtually all active genes. May also regulate transcription through direct binding to DNA or transcription factors. Belongs to the PBTF family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: DNA-dependent ATPase activity; protein binding; zinc ion binding; sequence-specific DNA binding; transcription factor binding

Biological Process: chromatin remodeling; anterior/posterior pattern formation; embryonic placenta development; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; brain development; endoderm development