Immunohistochemistry (IHC)
(Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
Rabbit anti-Human CNTNAP1 / CASPR / p190 Polyclonal Antibody | anti-CNTNAP1 antibody
Anti-CNTNAP1 / CASPR / p190 Antibody (aa926-1190) IHC-plus
IHC-P (1:100)
WB (1:100 - 1:400)
Immunohistochemistry (IHC)
(Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
Immunohistochemistry (IHC)
(Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE))
Western Blot (WB)
(Western blot of recombinant CNTNAP1 / CASPR / p190.)
Western Blot (WB)
(Western blot of recombinant CNTNAP1 / CASPR / p190.)
NCBI and Uniprot Product Information
NCBI Description
The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009]
Uniprot Description
CNTNAP1: Seems to play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the paranodal region of the axo-glial junction. In association with contactin may have a role in the signaling between axons and myelinating glial cells. Belongs to the neurexin family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q21
Cellular Component: integral to membrane; integral to plasma membrane; myelin sheath; paranode region of axon; voltage-gated potassium channel complex
Molecular Function: protein binding; receptor activity; SH3 domain binding; SH3/SH2 adaptor activity
Biological Process: action potential propagation; axon guidance; cell adhesion; cytoskeleton organization and biogenesis; neurite morphogenesis; neuromuscular process controlling balance; neuromuscular process controlling posture; paranodal junction assembly; positive regulation of signal transduction; signal transduction
Disease: Lethal Congenital Contracture Syndrome 7
Research Articles on CNTNAP1
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Product Notes
The CNTNAP1 cntnap1 (Catalog #AAA2400112) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-CNTNAP1 / CASPR / p190 Antibody (aa926-1190) IHC-plus reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CNTNAP1 / CASPR / p190 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC) Paraffin, Western Blot (WB), ELISA (EIA). ELISA (1:100 - 1:200) IHC-P (1:100) WB (1:100 - 1:400). Researchers should empirically determine the suitability of the CNTNAP1 cntnap1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CNTNAP1 / CASPR / p190, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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