Mouse COX 1, cyo-1 Monoclonal Antibody | anti-appC antibody

COX 1, cyo-1 (Cyclooxygenase-1, PGHS-1, Prostaglandin Endoperoxide Synthase-1, PHS 1, Ovarian Cancer Marker)

Cat. Num. AAA604389

• Gene Names: appC; cbdA; cyxA; ECK0969; JW0960
• Reactivity: Bovine, Human, Rat, Sheep
• Applications: ELISA, Immunohistochemistry
• Purity: Not Determined
• Synonyms: COX 1; cyo-1; Monoclonal Antibody; cyo-1 (Cyclooxygenase-1; PGHS-1; Prostaglandin Endoperoxide Synthase-1; PHS 1; Ovarian Cancer Marker); Anti -COX 1; anti-appC antibody

• Host: Mouse
• Reactivity: Bovine, Human, Rat, Sheep
• Clonality: Monoclonal
• Isotype: IgG2b
• Clone Number: 4i176
• Specificity: Reacts with sheep, bovine, human and rat PGHS-1. Does not react with guinea pig, rabbit, mouse or canine PGHS-1.
• Purity/Purification: Not Determined
• Form/Format: Supplied as liquid culture medium from the cyo-1 hybridoma cell line containing 0.1% sodium azide.

• Applicable Applications for anti-appC antibody: ELISA (EL/EIA), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in ELISA, Immunohistochemistry; Dilution: ELISA, Immunohistochemistry: 1:100-1:1000
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Related Product Information for anti-appC antibody

The prostanoid family includes PGD2, PGE2, PGF2alpha, PGI2, thromboxane A2 and prostaglandins. The prostaglandins (PGs) are implicated in various physiological and pathophysiological events, including male fertility, menstruation, ovulation, pregnancy, implantation and inflamatory and neoplastic diseases. The biosynthesis of PGs and some other prostanoids, is catalyzed in a rate limiting step by PG-H synthase (also known as cyclooxygenase (COX), PG-endoperoxidase synthase (PTGS)) which converts arachiodonic acid to prostaglandin/prostanoid precursor PGH2. Two cyclooxygenase isozymes, COX1 (human, 576aa, 69-72kD; chromosome 9) and COX2 (human, 604aa, 74kD; chromosome 1) have been identified. COX1, a constitutively expressed isoform, produces physiologically relevant prostanoids such as those in stomach and platelets. COX2 isoform is inducible and rapidly upregulated at inflamation sites and forms proinflamatory prostanoids. The overexpression of COX-2 also leads to tumerogenesis. Recently, a third isoform COX3 (canine 633aa; ~65kD in human aorta) has been reported. Two smaller COX1-derived proteins (partial COX1) PCOX1a (canine 414aa, ~53kDa in human aorta) and PCOX1b have also been characterized. The COX3, but not PCOX1a, possesses glycosylation dependent cyclooxygenase activity. The nonsteroidal antiinflammatory drugs (NSAIDs) reduce the formation of prostaglandins by inhibiting the activity of cyclooxygenases (COX1, COX2 and COX3), This ability was associated with inhibition of COX, which converts arachidonic acid to the prostaglandin precursor prostaglandin H2.

Product Categories/Family for anti-appC antibody

Antibodies; Abs to Enzymes; Cyclooxygenase (COX)

NCBI and Uniprot Product Information

• NCBI GI #: 114068
• NCBI GeneID: 945585
• NCBI Official Full Name: Cytochrome bd-II oxidase subunit 1
• NCBI Official Symbol: appC
• NCBI Official Synonym Symbols: cbdA; cyxA; ECK0969; JW0960
• NCBI Protein Information: cytochrome bd-II oxidase, subunit I
• Protein Family: Cytochrome bd-II ubiquinol oxidase

NCBI Description

EvgAS regulon. [More information is available at EcoGene: EG11380].