Rabbit anti-Human COX1 Polyclonal Antibody

COX1, CT (Prostaglandin G/H Synthase 1, Cyclooxygenase-1, COX-1, Prostaglandin-Endoperoxide Synthase 1, Prostaglandin H2 Synthase 1, PGH Synthase 1, PGHS-1, PHS 1, PTGS1)

Cat. Num. AAA6001237

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: COX1; Polyclonal Antibody; CT (Prostaglandin G/H Synthase 1; Cyclooxygenase-1; COX-1; Prostaglandin-Endoperoxide Synthase 1; Prostaglandin H2 Synthase 1; PGH Synthase 1; PGHS-1; PHS 1; PTGS1); Anti -COX1; anti-COX1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human Cyclooxygenase-1.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in 10mM PBS, pH 7.4, BSA, sodium azide.

• Applicable Applications for anti-COX1 antibody: Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 15ug/ml
• Immunogen: Synthetic peptide corresponding to human Cyclooxygenase-1 at C-terminal.
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Testing Data

(Human esophagus carcinoma using MBS6001237)

Immunohistochemistry (IHC)

(Human Small Intestine (formalin-fixed, paraffin-embedded) using MBS6001237 at 15ug/ml followed by biotinylated goat rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Immunohistochemistry (IHC)

(Human Skin (formalin-fixed, paraffin-embedded) using MBS6001237 at 15ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-COX1 antibody

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes PTGS1, which regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. PTGS1 is thought to be involved in cell-cell signaling and maintaining tissue homeostasis.

Product Categories/Family for anti-COX1 antibody

Antibodies; Abs to Enzymes; Cyclooxygenase (COX)

NCBI and Uniprot Product Information

• NCBI GI #: 543172662
• NCBI Official Full Name: COX1 (mitochondrion)
• Protein Family: Cox1 intron-like protein

Uniprot Description

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.