Mouse CD89 Monoclonal Antibody | anti-CD89 antibody

Anti-Hu CD89 PE

Cat. Num. AAA1800316

• Gene Names: FCAR; CD89; FcalphaRI; CTB-61M7.2
• Reactivity: Human, Non-human primates
• Applications: Flow Cytometry, Functional Assay
• Purity: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Synonyms: CD89; Monoclonal Antibody; Anti-Hu CD89 PE; Fc fragment of IgA receptor; FcalphaRI; FcAR; CTB-61M7.2; anti-CD89 antibody

• Host: Mouse
• Reactivity: Human, Non-human primates
• Clonality: Monoclonal
• Isotype: IgG1 kappa
• Clone Number: A59
• Specificity: The mouse monoclonal antibody A59 recognizes an extracellular epitope of CD89, a 55-100 kDa glycoprotein serving as a receptor for IgA and expressed mainly on granulocytes, monocytes and macrophages.
• Purity/Purification: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS) solution containing 15 mM sodium azide
• Sequence Length: 287

• Applicable Applications for anti-CD89 antibody: Flow Cytometry (FC/FACS)
• Application Notes: FC/FACS: QC tested
• Immunogen: Ag8.653 myeloma cells
• Conjugation: PE
• Preparation and Storage: Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light.

Flow Cytometry (FC/FACS)

(Flow cytometry analysis (surface staining) of CD89 in human peripheral blood with anti-CD89 (A59) PE.)

Related Product Information for anti-CD89 antibody

CD89 (Fc-alpha-R) is a type I transmembrane glycoprotein serving as a receptor for IgA. Soluble CD89 is detectable in serum and retains its IgA binding capacity. For signal transduction the association with FcR gamma chain homodimers is needed. CD89 is expressed on granulocytes, monocytes, macrophages, dendritic cells and myeloid cell lines. Its expression is upregulated in presence of IgA immune complexes, stimulators (such as LPS, PMA), TNF alpha, IL1 beta or GM-CSF, and it is downregulated in presence of TGF beta and suramin. Binding of IgA-opsonized targets to CD89 leads to phagocytic and cytotoxic processes of the immunologic defense.

NCBI and Uniprot Product Information

• NCBI GI #: 119860
• NCBI GeneID: 2204
• UniProt Accession #: P24071
• NCBI Official Full Name: Immunoglobulin alpha Fc receptor
• NCBI Official Synonym Full Names: Fc fragment of IgA receptor
• NCBI Official Symbol: FCAR
• NCBI Official Synonym Symbols: CD89; FcalphaRI; CTB-61M7.2
• NCBI Protein Information: immunoglobulin alpha Fc receptor
• UniProt Protein Name: Immunoglobulin alpha Fc receptor
• UniProt Gene Name: FCAR
• UniProt Synonym Gene Names: CD89; IgA Fc receptor

NCBI Description

This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.